Document Detail

Pregnancy outcomes in women with elevated levels of fetal hemoglobin.
MedLine Citation:
PMID:  21473677     Owner:  NLM     Status:  Publisher    
Objective. Elevated maternal levels of fetal hemoglobin (HbF) present a unique situation where both mother and fetus produce hemoglobin with equivalent oxygen affinities. We aimed to determine pregnancy outcomes in women with persistently elevated HbF. Methods. In this retrospective cohort study, women with HbF levels exceeding 10% were identified by searching a provincial database. Maternal, obstetric, and neonatal outcomes were extracted from chart reviews performed at two hospitals. Results. Twenty-two women with a total of 43 pregnancies and 33 live births were identified. Maternal levels of HbF ranged between 11 and 100%. Women with HbF ≥ 70% were significantly more likely to deliver growth-restricted or small for gestational age (SGA) fetuses compared to the group of women with HbF <70% (100% versus 8%; p <0.01). Three women (4/32 pregnancies) received blood transfusions, which was unrelated to HbF levels. Conclusions. Pregnancies complicated by maternal HbF levels ≥ 70% are at increased risk of intra-uterine growth restriction or SGA fetuses. Increased antenatal surveillance is suggested.
Ally Murji; Mara L Sobel; Lara Hasan; Anne McLeod; John S Waye; Mathew Sermer; Howard Berger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-7
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
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