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Pregnancy outcomes in women with moderate-to-severe psoriasis.
MedLine Citation:
PMID:  21108670     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background  The association between psoriasis and pregnancy outcomes has not been adequately examined, although psoriasis onset is common in the reproductive period. Objective  To evaluate the association between moderate-to-severe psoriasis and pregnancy complications. Methods  A retrospective, matched cohort study of 68 deliveries in 35 women with moderate-to-severe psoriasis compared to 237 deliveries in 236 women without psoriasis randomly selected after matching for age, parity and gestational age. Results  The psoriasis patients had higher mean of past spontaneous (0.42 ± 0.58 vs. 0.26 ± 0.63, P = 0.002) and induced (0.32 ± 0.60 vs. 0.06 ± 0.25, P = 0.001) abortions than controls. They had a higher percentage of pregnancy-induced hypertensive diseases (7.4% vs. 2.1%, P < 0.05) and premature rupture of membranes (16% vs. 5.5%, P < 0.008). Newborns to women with psoriasis had higher birth weight (3375 ± 543 g vs. 3247 ± 460 g, P = 0.03), increased percentage of large-for-gestational age (24% vs. 12%, P = 0.02), and macrosomia (13% vs. 4.2%P = 0.02). In multivariate analysis, moderate-to-severe psoriasis was an independent risk factor for previous spontaneous abortions, induced abortions, premature rupture of membranes (PROM), and newborn macrosomia. Conclusion  Moderate-to-severe psoriasis is associated with spontaneous and induced abortions, pregnancy-induced hypertensive diseases, premature rupture of membranes, large-for-gestational age newborns, and macrosomia.
Authors:
E Cohen-Barak; Z Nachum; D Rozenman; M Ziv
Publication Detail:
Type:  Journal Article     Date:  2010-11-25
Journal Detail:
Title:  Journal of the European Academy of Dermatology and Venereology : JEADV     Volume:  25     ISSN:  1468-3083     ISO Abbreviation:  J Eur Acad Dermatol Venereol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216037     Medline TA:  J Eur Acad Dermatol Venereol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1041-7     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.
Affiliation:
Departments of DermatologyObstetrics and Gynecology, Ha'emek Medical Center, AfulaRappaport School of Medicine, Technion, Haifa, Israel.
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