Document Detail


Pregnancy outcomes in women infected with Chlamydia trachomatis: a population-based cohort study in Washington State.
MedLine Citation:
PMID:  17344249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To measure the risk of preterm delivery, premature rupture of membranes, infant low birth weight and infant mortality, by a population-based retrospective cohort study using Washington State birth certificate data.
METHODS: All women diagnosed with Chlamydia trachomatis infection (n = 851), noted with a check box on the birth certificate from 2003, and a randomly selected sample of women not diagnosed with C trachomatis (n = 3404) were identified. To assess the RR between chlamydia infection and pregnancy outcomes, multivariable logistic regression analysis was used.
RESULTS: Women with chlamydia infection were younger, more likely to be non-white and had less years of education compared with women without chlamydia. Additionally, they were more likely to have inadequate prenatal care and coinfections with other sexually transmitted infections. After adjusting for age and education, chlamydia-infected women were at an increased risk of preterm delivery (RR 1.46, 95% CI 1.08 to 1.99) and premature rupture of membranes (RR 1.50, 95% CI 1.03 to 2.17) compared with non-infected women. However, no increased risk of infant death (RR 1.02, 95% CI 0.37 to 2.80) or low birth weight (RR 1.12, 95% CI 0.74 to 1.68) associated with chlamydia infection was observed.
CONCLUSION: This study suggests that C trachomatis is associated with an increased risk of preterm delivery and premature rupture of membranes, but not with infant death and low birth weight. Routine screening and opportune treatment for C trachomatis should be considered a necessary part of prenatal care to reduce these adverse pregnancy outcomes.
Authors:
Magaly M Blas; Fredy A Canchihuaman; Isaac E Alva; Stephen E Hawes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-03-07
Journal Detail:
Title:  Sexually transmitted infections     Volume:  83     ISSN:  1368-4973     ISO Abbreviation:  Sex Transm Infect     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-31     Completed Date:  2007-09-18     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9805554     Medline TA:  Sex Transm Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  314-8     Citation Subset:  IM    
Affiliation:
Department of Epidemiology,School of Public Health and Community Medicine, University of Washington, Seattle, WA 98103, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Chlamydia Infections / epidemiology*
Chlamydia trachomatis*
Cohort Studies
Female
Fetal Membranes, Premature Rupture / epidemiology*
Humans
Multivariate Analysis
Obstetric Labor, Premature / epidemiology*
Pregnancy
Pregnancy Complications, Infectious / epidemiology*
Pregnancy Outcome / epidemiology
Retrospective Studies
Risk Factors
Washington / epidemiology
Grant Support
ID/Acronym/Agency:
D43TW00007/TW/FIC NIH HHS; D43TW007551/TW/FIC NIH HHS
Comments/Corrections

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