| Pregnancy outcomes in pulmonary arterial hypertension in the modern management era. | |
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MedLine Citation:
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PMID: 22282544 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Previous studies have reported mortality rates of up to 56% associated with pregnancy in pulmonary arterial hypertension (PAH) but the management of this disease has changed considerably in recent years.We conducted a multinational, prospective registry to examine the contemporary outcome of pregnancies in patients with PAH.During a 3-year period, the 13 participating centres reported 26 pregnancies. Three females (12%) died and one (4%) developed right heart failure requiring urgent heart-lung transplantation. There were 8 abortions; 2 spontaneous and 6 induced. Sixteen pregnancies (62%) were successful, i.e. the females delivered healthy babies without complications. These females had well controlled PAH (pulmonary vascular resistance, PVR, 500±352 dyn.s.cm(-5)); eight of them were long-term responders to calcium channel blockers. In contrast, the females who died or required transplantation had poorly controlled PAH (PVR, 1,667±209 dyn.s.cm(-5)).Pregnancy remains associated with a substantial mortality rate in PAH. However, our results indicate that the outcome of pregnancies in PAH has improved, at least when PAH is well controlled and particularly in long-term responders to calcium channel blockers. These data must be confirmed by larger series before the general recommendation to avoid pregnancy in all patients with PAH is reconsidered. |
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Authors:
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X Jaïs; K M Olsson; J A Barbera; I Blanco; A Torbicki; A Peacock; C D Vizza; P Macdonald; M Humbert; M M Hoeper |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-26 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Faculté de Médecine, Le Kremlin-Bicêtre, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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