Document Detail


Pregnancy outcomes in oocyte donation recipients: vaginal gel versus intramuscular injection progesterone replacement.
MedLine Citation:
PMID:  22310935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Compare outcomes with vaginal gel versus intramuscular progesterone replacement in donor oocyte recipients.
METHODS: A single-center retrospective analysis (January 2004-December 2006) evaluated pregnancy outcomes (serum human chorionic gonadotropin, implantation, clinical pregnancy, delivery, total pregnancy loss rates) for 225 recipients of embryos from donor (aged <32 years) oocytes. Vaginal progesterone gel (Crinone® 8%; 90 mg twice daily; n = 105) or intramuscular progesterone (50 mg once daily; n = 120) was started the afternoon of oocyte retrieval and continued until a negative pregnancy test or 10 weeks' gestation.
RESULTS: There were no statistically significant differences between groups for the five pregnancy outcomes; numerical results favored vaginal progesterone in all cases. Confidence intervals showed vaginal gel was within, or <1% from, a noninferiority limit of 10% versus intramuscular progesterone for four of five pregnancy outcomes.
CONCLUSIONS: Pregnancy outcomes were comparable for progesterone replacement with vaginal gel and intramuscular progesterone in an oocyte donation program.
Authors:
Brian M Berger; James A Phillips
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-02-04
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-28     Completed Date:  2012-07-03     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  237-42     Citation Subset:  IM    
Affiliation:
Boston IVF, Inc., Waltham, MA 02451, USA. BBerger@BOSTONIVF.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Chorionic Gonadotropin / blood
Delayed-Action Preparations / administration & dosage,  therapeutic use
Embryo Transfer*
Female
Fertilization in Vitro
Hormone Replacement Therapy*
Humans
Infertility / blood,  therapy*
Injections, Intramuscular
Middle Aged
Oocyte Donation*
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Progesterone / administration & dosage*,  analogs & derivatives,  therapeutic use
Retrospective Studies
Sperm Injections, Intracytoplasmic
Vaginal Creams, Foams, and Jellies
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Crinone; 0/Delayed-Action Preparations; 0/Vaginal Creams, Foams, and Jellies; 57-83-0/Progesterone
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