Document Detail

Pregnancy outcomes in multiple sclerosis following subcutaneous interferon beta-1a Therapy.
MedLine Citation:
PMID:  21220368     Owner:  NLM     Status:  Publisher    
Background: Women with multiple sclerosis (MS) are advised to discontinue interferon-beta therapy before trying to conceive. Unplanned pregnancies occur and risks related to exposure remain unclear. Methods: To determine pregnancy outcomes following interferon-beta therapy, we examined pregnancies from a global drug safety database containing individual case safety reports received in the post-marketing setting and safety data from clinical trials of subcutaneous interferon beta-1a in MS. Results: One thousand and twenty-two cases of exposure to subcutaneous interferon beta-1a during pregnancy were retrieved; 679 had a documented outcome. In cases for which exposure duration was available (n = 231), mean time of foetal exposure to subcutaneous interferon beta-1a before treatment discontinuation was 28 days; most pregnancies (199/231; 86.1%) were exposed for ≤45 days. To avoid bias, only outcomes for prospective data (n = 425) in pregnancies exposed to interferon beta-1a in utero were analysed further. Of these, 324 (76.2%) resulted in normal live births and four (0.9%) in live births with congenital anomalies (3 [0.7%] were 'major'). Four (0.9%) pregnancies resulted in stillbirths (1 [0.2%] with foetal defects). There were 5 (1.2%) ectopic pregnancies, 49 (11.5%) spontaneous abortions and 39 (9.2%) elective terminations. Most pregnancies exposed to subcutaneous interferon beta-1a in utero were associated with normal live births. The rates of spontaneous abortion and major congenital anomalies in live births were in line with those observed in the general population. Conclusions: These data should be taken into account when considering options for women with MS who become pregnant or who are planning pregnancy while on treatment with subcutaneous interferon beta-1a.
Magnhild Sandberg-Wollheim; Enrica Alteri; Margaretha Stam Moraga; Gabrielle Kornmann
Related Documents :
17561008 - A combined intrauterine and cervical pregnancy diagnosed in the 13th gestational week: ...
21422868 - Pregnancy in women with physical disabilities.
23841018 - Trimester-specific reference ranges for thyroid hormones in iranian pregnant women.
8475438 - The effect of multilevel laminectomy on the cervical spine of growing cats. an experime...
23814688 - Magnetic resonance imaging as an adjunct to ultrasound in evaluating cesarean scar ecto...
12196848 - Use of low molecular weight heparin in acute venous thromboembolic events in pregnancy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-10
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  -     ISSN:  1477-0970     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Neurology, University Hospital, Lund, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Resuscitation of warm ischaemia predamaged porcine kidneys by fibrinolytic preflush with streptokina...
Next Document:  Association between serum gamma-glutamyltransferase activity and carotid intima-media thickness.