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Pregnancy outcomes among solid organ transplant recipients in british columbia.
MedLine Citation:
PMID:  22555133     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective: Since 1954, over 14 000 women have given birth after having had an organ transplantation. Unfortunately, some women and physicians remain misinformed about the feasibility and outcomes of pregnancy post transplantation. Our primary objective was to assess their perceptions and difficulties with regard to becoming pregnant. Our secondary objectives were to determine the incidence of pregnancies among transplant recipients in British Columbia and any maternal, graft, or fetal complications. Methods: From 1997 to 2007 in British Columbia, there were over 500 female recipients of solid organ transplants. We surveyed recipients in this group who were of child-bearing age. Results: One hundred forty of 295 (47%) eligible recipients responded: 44 of these women had attempted pregnancy after transplant, and 31 women gave birth to 47 children. One half of the respondents planned to have children post transplant; 108 of 140 (77%) had no children before transplant. One quarter of the respondents were advised against pregnancy by their physician, and 33% of these women found a new physician to support their pregnancy. Rates of miscarriage (27%), rejection (21%), and prematurity (65%) were higher than expected. Infections were rare, and no birth defects or noteworthy health problems in the offspring were reported. Conclusions: Overall, pregnancy appears to be safe following solid organ transplantation, but careful monitoring and counselling are recommended.
Authors:
Robert A Humphreys; Helen H L Wong; Ruth Milner; Mina Matsuda-Abedini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC     Volume:  34     ISSN:  1701-2163     ISO Abbreviation:  J Obstet Gynaecol Can     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126664     Medline TA:  J Obstet Gynaecol Can     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  416-24     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, British Columbia's Children's Hospital, University of British Columbia, Vancouver BC, Division of Nephrology, British Columbia's Children's Hospital, University of British Columbia, Vancouver BC.
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