Document Detail

Pregnancy outcomes after increasing maternal serum alpha-fetoprotein levels.
MedLine Citation:
PMID:  2471946     Owner:  NLM     Status:  MEDLINE    
Five hundred sixty women among 35,787 screened had an initial maternal serum alpha-fetoprotein (MSAFP) of 2.5 or more multiples of the median. They were divided into three groups: group 1, 2.5-2.9; group 2, 3.0-3.9; and group 3, over 4.0 multiples of the median. These groupings determined the relationship to adverse pregnancy outcome, defined as fetal death, fetus with significant anomalies, and prematurity/growth retardation. The overall risk of adverse outcome after an initial elevation was 38%, after excluding pregnancies with incorrect dates or multiple gestations with levels below 4.5 multiples of the median: 27, 39, and 45% in groups 1, 2, and 3, respectively. This risk rose to 86% for levels over 6.0 multiples of the median. There was a significant positive correlation between abnormalities and death detected with ultrasound and amniocentesis and those indicated by increasing MSAFP levels: 10, 20, and 31% in groups 1, 2, and 3, respectively. After normal ultrasound and amniocentesis studies, there was a trend toward increasing risks for fetal death after 20 weeks between groups 2 and 3 (5 and 11%), but not for growth retardation/prematurity (12, 17, and 13%). After an elevated MSAFP, the overall risk of a late pregnancy complication after normal ultrasound and amniocentesis was 22%: 19, 23, and 25% in groups 1, 2, and 3, respectively. This figure increased to 67% for levels above 6.0 multiples of the median.
L Robinson; P Grau; B F Crandall
Related Documents :
11584086 - Dietary methionine is involved in the etiology of neural tube defect-affected pregnanci...
10539786 - Folic acid supplementation of pregnant mice suppresses heat-induced neural tube defects...
12531736 - Effect of cortisol on norepinephrine-mediated contractions in ovine uterine arteries.
20014436 - Association of high-dose bifonazole administration during early pregnancy and severe li...
4018276 - Increased maternal serum 3 alpha, 17 beta-androstanediol glucuronide concentrations dur...
15691136 - Scrub typhus during pregnancy: a case report and review of the literature.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  74     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-07-21     Completed Date:  1989-07-21     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  17-20     Citation Subset:  AIM; IM    
Department of Psychiatry, University of California, Los Angeles.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Congenital Abnormalities / diagnosis,  epidemiology
Fetal Death / epidemiology
Infant, Low Birth Weight
Infant, Newborn
Predictive Value of Tests
Pregnancy Outcome*
Prenatal Care / methods*
Prenatal Diagnosis
alpha-Fetoproteins / metabolism*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Maternal serum alpha-fetoprotein (MSAFP) screening: the Keesler experience.
Next Document:  ABLETOP, a well-tolerated, effective regimen for relapsing Hodgkin's disease. Swiss Group for Clinic...