| Pregnancy outcomes after increasing maternal serum alpha-fetoprotein levels. | |
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MedLine Citation:
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PMID: 2471946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Five hundred sixty women among 35,787 screened had an initial maternal serum alpha-fetoprotein (MSAFP) of 2.5 or more multiples of the median. They were divided into three groups: group 1, 2.5-2.9; group 2, 3.0-3.9; and group 3, over 4.0 multiples of the median. These groupings determined the relationship to adverse pregnancy outcome, defined as fetal death, fetus with significant anomalies, and prematurity/growth retardation. The overall risk of adverse outcome after an initial elevation was 38%, after excluding pregnancies with incorrect dates or multiple gestations with levels below 4.5 multiples of the median: 27, 39, and 45% in groups 1, 2, and 3, respectively. This risk rose to 86% for levels over 6.0 multiples of the median. There was a significant positive correlation between abnormalities and death detected with ultrasound and amniocentesis and those indicated by increasing MSAFP levels: 10, 20, and 31% in groups 1, 2, and 3, respectively. After normal ultrasound and amniocentesis studies, there was a trend toward increasing risks for fetal death after 20 weeks between groups 2 and 3 (5 and 11%), but not for growth retardation/prematurity (12, 17, and 13%). After an elevated MSAFP, the overall risk of a late pregnancy complication after normal ultrasound and amniocentesis was 22%: 19, 23, and 25% in groups 1, 2, and 3, respectively. This figure increased to 67% for levels above 6.0 multiples of the median. |
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Authors:
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L Robinson; P Grau; B F Crandall |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 74 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-07-21 Completed Date: 1989-07-21 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 17-20 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, University of California, Los Angeles. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amniocentesis Congenital Abnormalities / diagnosis, epidemiology Female Fetal Death / epidemiology Humans Infant, Low Birth Weight Infant, Newborn Predictive Value of Tests Pregnancy Pregnancy Outcome* Prenatal Care / methods* Prenatal Diagnosis Risk Ultrasonography alpha-Fetoproteins / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HD 07032/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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