Document Detail


Pregnancy outcomes after conservative surgical management of ovarian neoplasms treated at a single institution.
MedLine Citation:
PMID:  20683397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HYPOTHESIS: Conservative surgical management of ovarian neoplasms can result in favorable oncologic and obstetric outcomes. METHODS: All reproductive-age women (18-45 years old) with stage IA to stage IIC ovarian neoplasms (N = 161) were retrospectively identified from a single institution's tumor registry between 1990 and 2007. Operative, pathological, outpatient, and delivery records were reviewed to confirm histological findings, stage, extent of surgical resection, adjuvant treatment, oncologic outcomes, and pregnancy outcomes. RESULTS: Women who underwent conservative surgical management for ovarian neoplasms (n = 61 [37.9%]) were identified, including those with low malignant potential (LMP, n = 36), epithelial (n = 12), germ cell (n = 6), and sex cord (n = 7) tumors. Thirteen women conceived 23 pregnancies, producing a pregnancy rate of 25.0% overall and of 68.4% for those attempting conception. Women with LMP tumors conceived most pregnancies and had the highest number of antenatal complications. Of those receiving adjuvant chemotherapy (n = 8), 12.5% were able to conceive after their treatment and with no reported congenital anomalies. Pregnancy after a diagnosis of ovarian neoplasm did not impact disease recurrence (0% vs 7.7%, P = 0.56) or survival (100% vs 100%, P = 1.0). CONCLUSIONS: Conservative surgery may be an acceptable option for reproductive-age women with early-stage ovarian neoplasms. We report pregnancy and oncologic outcomes for a cohort of women managed conservatively for LMP, epithelial, germ cell, and sex cord ovarian neoplasms.
Authors:
Gina M Mantia Smaldone; Scott D Richard; Robert P Edwards
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society     Volume:  20     ISSN:  1525-1438     ISO Abbreviation:  Int. J. Gynecol. Cancer     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-04     Completed Date:  2010-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111626     Medline TA:  Int J Gynecol Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  926-31     Citation Subset:  IM    
Affiliation:
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. gina.mantia@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Academic Medical Centers
Adolescent
Adult
Biopsy, Needle
Chemotherapy, Adjuvant
Female
Follow-Up Studies
Humans
Immunohistochemistry
Middle Aged
Neoplasm Staging
Ovarian Neoplasms / pathology,  surgery*
Ovariectomy / methods*
Pregnancy
Pregnancy Complications, Neoplastic / drug therapy,  pathology,  surgery*
Pregnancy Outcome*
Pregnancy Rate / trends
Registries
Retrospective Studies
Risk Assessment
Surgical Procedures, Minimally Invasive / methods
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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