Document Detail


Pregnancy outcome of women transfused during pregnancy with blood products inadvertently obtained from donors treated with acitretin.
MedLine Citation:
PMID:  19821659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed the pregnancy outcome of nine women inadvertently transfused with acitretin-contaminated blood products in South Korea. A total of 18 women matched to cases by age, gravidity, and singleton- or twin-pregnancy, and who were transfused with blood products not contaminated with acitretin, was also recruited. There were nine babies born in the case group. No differences (p > 0.05) were observed between cases and controls in the gestational age at delivery (38.3 +/- 1.6 weeks vs 37.8 +/- 2.2 weeks), birth weight (3,146 +/- 874 g vs 3,106 +/- 568 g), rate of pre-term deliveries (22.2% vs 11.1%) and rate of low birth weight (<2,500 g) (33.3% vs 16.7%). There was no case of malformation or neurological abnormalities born in either group. In conclusion, inadvertent exposure to acitretin-contaminated blood products was not associated with adverse pregnancy outcomes, probably because of the removal of acitretin and etretinate during the manufacturing process of blood products.
Authors:
J Y Han; J S Choi; J M Chun; H D Park; S Y Lee; C H Kim; Q Park; A A Nava-Ocampo; G Koren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  29     ISSN:  1364-6893     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-13     Completed Date:  2010-01-04     Revised Date:  2010-04-08    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  694-7     Citation Subset:  IM    
Affiliation:
Korean Motherisk Program, Department of Obstetrics and Gynecology, Cheil Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea. hanjungyeol@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Acitretin / blood*
Adult
Biological Products / chemistry*
Blood Transfusion / adverse effects*
Case-Control Studies
Drug Contamination
Female
Gestational Age
Half-Life
Humans
Infant, Newborn
Keratolytic Agents / blood*
Pregnancy
Pregnancy Outcome*
Psoriasis / blood,  drug therapy
Teratogens
Chemical
Reg. No./Substance:
0/Biological Products; 0/Keratolytic Agents; 0/Teratogens; 55079-83-9/Acitretin
Comments/Corrections
Comment In:
J Obstet Gynaecol. 2010 Apr;30(3):333; author reply 334   [PMID:  20373953 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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