| Pregnancy outcome of women transfused during pregnancy with blood products inadvertently obtained from donors treated with acitretin. | |
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MedLine Citation:
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PMID: 19821659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We assessed the pregnancy outcome of nine women inadvertently transfused with acitretin-contaminated blood products in South Korea. A total of 18 women matched to cases by age, gravidity, and singleton- or twin-pregnancy, and who were transfused with blood products not contaminated with acitretin, was also recruited. There were nine babies born in the case group. No differences (p > 0.05) were observed between cases and controls in the gestational age at delivery (38.3 +/- 1.6 weeks vs 37.8 +/- 2.2 weeks), birth weight (3,146 +/- 874 g vs 3,106 +/- 568 g), rate of pre-term deliveries (22.2% vs 11.1%) and rate of low birth weight (<2,500 g) (33.3% vs 16.7%). There was no case of malformation or neurological abnormalities born in either group. In conclusion, inadvertent exposure to acitretin-contaminated blood products was not associated with adverse pregnancy outcomes, probably because of the removal of acitretin and etretinate during the manufacturing process of blood products. |
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Authors:
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J Y Han; J S Choi; J M Chun; H D Park; S Y Lee; C H Kim; Q Park; A A Nava-Ocampo; G Koren |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology Volume: 29 ISSN: 1364-6893 ISO Abbreviation: J Obstet Gynaecol Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-13 Completed Date: 2010-01-04 Revised Date: 2010-04-08 |
Medline Journal Info:
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Nlm Unique ID: 8309140 Medline TA: J Obstet Gynaecol Country: England |
Other Details:
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Languages: eng Pagination: 694-7 Citation Subset: IM |
Affiliation:
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Korean Motherisk Program, Department of Obstetrics and Gynecology, Cheil Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea. hanjungyeol@yahoo.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acitretin
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blood* Adult Biological Products / chemistry* Blood Transfusion / adverse effects* Case-Control Studies Drug Contamination Female Gestational Age Half-Life Humans Infant, Newborn Keratolytic Agents / blood* Pregnancy Pregnancy Outcome* Psoriasis / blood, drug therapy Teratogens |
| Chemical | |
Reg. No./Substance:
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0/Biological Products; 0/Keratolytic Agents; 0/Teratogens; 55079-83-9/Acitretin |
| Comments/Corrections | |
Comment In:
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J Obstet Gynaecol. 2010 Apr;30(3):333; author reply 334
[PMID:
20373953
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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