| Pregnancy outcome in women with vitiligo. | |
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MedLine Citation:
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PMID: 22126869 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background Vitiligo, characterized by destruction of melanocytes, causes a patchy depigmentation of the skin. It has been hypothesized to have an autoimmune pathogenesis. Autoimmune disorders are more common among women and may be associated with adverse pregnancy outcomes, such as recurrent abortions, intrauterine growth restriction (IUGR), and pre-eclampsia. Objective The purpose of this study was to investigate whether patients with vitiligo have increased rates of gestational complications. Methods A retrospective comparative study was undertaken comparing pregnancy complications of patients with and without vitiligo. The population was composed of all singleton deliveries that occurred at the Soroka University Medical Center in Israel during the years 1988-2006. Women lacking prenatal care and multiple gestations were excluded from the study. A multivariable logistic regression model was constructed to control for confounders. Results Of 186,222 singleton deliveries, 79 (0.04%) were patients with vitiligo. Vitiligo was not found to be associated with adverse pregnancy outcomes, including obstetric risk factors, labor characteristics and complications, and birth outcome. Using multivariable analysis, only grand multiparity (above five deliveries) was independently associated with vitiligo (OR = 2.01; 95% CI 1.2-3.2; P = 0.007). Limitations Retrospective analysis was a limitation. Conclusion Vitiligo is not associated with adverse pregnancy outcomes. Accordingly, patients with vitiligo should not be managed differently from the general obstetric population. |
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Authors:
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Amir Horev; Adi Y Weintraub; Ruslan Sergienko; Arnon Wiznitzer; Sima Halevy; Eyal Sheiner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of dermatology Volume: 50 ISSN: 1365-4632 ISO Abbreviation: Int. J. Dermatol. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243704 Medline TA: Int J Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 1083-5 Citation Subset: IM |
Copyright Information:
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© 2011 The International Society of Dermatology. |
Affiliation:
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Departments of Dermatology and Venereology Obstetrics and Gynecology, Soroka University Medical Center, Beer-Sheva Epidemiology and Health Services Evaluation, Ben-Gurion University of the Negev, Beer-Sheva, Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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