| Pregnancy outcome in women with pre-existing lupus nephritis. | |
| | |
MedLine Citation:
|
PMID: 16147600 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of the present study was to assess the fetal and maternal outcome in a cohort of patients with lupus nephritis. Twenty-four pregnancies in 22 women with lupus nephritis occurring between 1991 and 2000 were analysed retrospectively. Lupus nephritis was biopsy proven before pregnancy in all cases. Women were followed from the beginning of pregnancy up to 6 months postpartum. Close fetal-maternal monitoring and frequent laboratory investigations were applied routinely to all patients. All women were prescribed steroid therapy from the beginning of the pregnancy. There were 18 live births, four spontaneous abortions and two stillbirths. Of the 18 live births, 14 were premature and four were term deliveries, representing a 25% fetal loss rate and 58% prematurity rate. There were two fetuses with congenital heart block. We recorded hypertension in 42%, proteinuria in 50% and pre-eclampsia in 25% of our patients. Proteinuria was irreversible in four cases. No maternal deaths or postpartum exacerbation of the disease were recorded in the study period. All renal flares were reversed postpartum. Patients positive for antiphospholipid antibodies had a worse perinatal outcome. Hypertension, proteinuria and antiphospholipid antibodies appear to be associated with adverse perinatal outcome and pregnancy complications. Pregnancy is not contraindicated in women with lupus nephritis, but is associated with significant fetal and maternal risks. |
| | |
Authors:
|
L Soubassi; D Haidopoulos; M Sindos; A Pilalis; D Chaniotis; E Diakomanolis; A Antsaklis; N Zerefos |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology Volume: 24 ISSN: 0144-3615 ISO Abbreviation: J Obstet Gynaecol Publication Date: 2004 Sep |
Date Detail:
|
Created Date: 2005-09-08 Completed Date: 2005-09-22 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8309140 Medline TA: J Obstet Gynaecol Country: England |
Other Details:
|
Languages: eng Pagination: 630-4 Citation Subset: IM |
Affiliation:
|
Department of Nephrology, Alexandra Hospital, Athens, Greece. katsioli@otenet.gr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortion, Spontaneous
/
epidemiology Antibodies, Antiphospholipid / blood Birth Weight Cesarean Section / statistics & numerical data Female Fetal Death / epidemiology Gestational Age Humans Hypertension / complications Infant, Newborn Infant, Premature Lupus Nephritis / complications*, immunology Obstetric Labor, Premature Pregnancy Pregnancy Complications* Pregnancy Outcome* Prognosis Proteinuria / complications Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Antiphospholipid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mode of delivery and birth outcomes of macrosomic infants.
Next Document: The effect of intermittent maternal fasting on human fetal breathing movements.