Document Detail

Pregnancy outcome in women with pre-existing lupus nephritis.
MedLine Citation:
PMID:  16147600     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to assess the fetal and maternal outcome in a cohort of patients with lupus nephritis. Twenty-four pregnancies in 22 women with lupus nephritis occurring between 1991 and 2000 were analysed retrospectively. Lupus nephritis was biopsy proven before pregnancy in all cases. Women were followed from the beginning of pregnancy up to 6 months postpartum. Close fetal-maternal monitoring and frequent laboratory investigations were applied routinely to all patients. All women were prescribed steroid therapy from the beginning of the pregnancy. There were 18 live births, four spontaneous abortions and two stillbirths. Of the 18 live births, 14 were premature and four were term deliveries, representing a 25% fetal loss rate and 58% prematurity rate. There were two fetuses with congenital heart block. We recorded hypertension in 42%, proteinuria in 50% and pre-eclampsia in 25% of our patients. Proteinuria was irreversible in four cases. No maternal deaths or postpartum exacerbation of the disease were recorded in the study period. All renal flares were reversed postpartum. Patients positive for antiphospholipid antibodies had a worse perinatal outcome. Hypertension, proteinuria and antiphospholipid antibodies appear to be associated with adverse perinatal outcome and pregnancy complications. Pregnancy is not contraindicated in women with lupus nephritis, but is associated with significant fetal and maternal risks.
L Soubassi; D Haidopoulos; M Sindos; A Pilalis; D Chaniotis; E Diakomanolis; A Antsaklis; N Zerefos
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  24     ISSN:  0144-3615     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2005-09-08     Completed Date:  2005-09-22     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  630-4     Citation Subset:  IM    
Department of Nephrology, Alexandra Hospital, Athens, Greece.
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MeSH Terms
Abortion, Spontaneous / epidemiology
Antibodies, Antiphospholipid / blood
Birth Weight
Cesarean Section / statistics & numerical data
Fetal Death / epidemiology
Gestational Age
Hypertension / complications
Infant, Newborn
Infant, Premature
Lupus Nephritis / complications*,  immunology
Obstetric Labor, Premature
Pregnancy Complications*
Pregnancy Outcome*
Proteinuria / complications
Retrospective Studies
Risk Factors
Reg. No./Substance:
0/Antibodies, Antiphospholipid

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