Document Detail

Pregnancy outcome in systemic sclerosis.
MedLine Citation:
PMID:  9251376     Owner:  NLM     Status:  MEDLINE    
The outcome of pregnancy in systemic scleroderma (SSc) has been a subject of much interest. In a retrospective analysis of 59 pregnancies of 17 mothers with SSc, the effect of disease on pregnancy outcome was variable. There was no adverse effect on fertility. While there was an apparent decrease in fertility in the limited cutaneous disease, this was not seen in the diffuse variety. There was an decreased incidence of live birth after the onset of disease as compared prior to the onset of disease. The foetal wastage after the onset of disease was contributed equally by spontaneous abortions as well as induced terminations of pregnancies. The presence of anticardiolipin antibodies was not related with adverse outcome. The effect of pregnancy on disease was variable with the disease being stable in five patients, regressing in five and progressing in three. The increased terminations of pregnancy reflects the uncertainities of positive outcome both by parent and attending physicians.
A Wanchu; R Misra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  44     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-08-29     Completed Date:  1997-08-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  637-40     Citation Subset:  IM    
Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, India.
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MeSH Terms
Cohort Studies
India / epidemiology
Pregnancy Complications* / diagnosis,  epidemiology
Pregnancy Outcome
Retrospective Studies
Scleroderma, Systemic* / complications,  diagnosis,  epidemiology

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