Document Detail

Pregnancy outcome in survivors of advanced Hodgkin disease.
MedLine Citation:
PMID:  1623485     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pregnancy outcome was reported by 139 survivors of advanced Hodgkin disease treated on nine protocols of Cancer and Leukemia Group B from 1966 to 1986. METHODS: These patients provided data on 302 singleton pregnancies of a duration of at least 20 weeks that occurred before, during, or after treatment for Hodgkin disease (252, 26, and 24 pregnancies, respectively). RESULTS: There were 4 perinatal deaths, as compared with 5.7 expected. Cancer subsequently developed in 2 offspring (expected, 1.2). However, 22 newborn infants had low a birth weight, exceeding the expected number of 13.7 (relative risk 1.6; 95% confidence interval, 1.0-2.4). The excess number of low weight births occurred primarily during the period of Hodgkin disease diagnosis and treatment but is based on small numbers. CONCLUSION: No increase in adverse outcome occurred in pregnancies that antedated the development of Hodgkin disease.
A J Janov; J Anderson; D F Cella; E Zuckerman; A B Kornblith; J C Holland; A F Kantor; F P Li; E Henderson; R B Weiss
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  70     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-08-07     Completed Date:  1992-08-07     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  688-92     Citation Subset:  AIM; IM    
Clinical Epidemiology Branch, National Cancer Institute, Bethesda, Maryland.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Epidemiologic Methods
Hodgkin Disease / drug therapy,  physiopathology*
Middle Aged
Pregnancy Complications / epidemiology*
Pregnancy Outcome / epidemiology*
Grant Support
Erratum In:
Cancer 1993 Jan 15;71(2):492

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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