Document Detail


Pregnancy outcome in recurrent aborters is not influenced by Chlamydia IgA and/or G.
MedLine Citation:
PMID:  15667525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PROBLEM: It is unclear whether chlamydia infection influences the miscarriage rate and immunological factors in patients with recurrent miscarriage. METHOD OF STUDY: Chlamydia DNA, IgA and IgG to Chlamydia trachomatis, natural killer cell activity, complement 3 (C3), C4, hemolytic complement, antinuclear antibodies, antiphospholipid antibodies, prolactin, activated partial thromboplastin time, prothrombin time and fibrinogen were examined in 504 patients with a history of two or more consecutive first-trimester miscarriages. Subsequent pregnancy outcomes were compared between cases with and without antibodies to C. trachomatis. RESULTS: Totals of 10 of 30 and 48 of 201 patients receiving no medication miscarried subsequently with and without chlamydia infection. Chlamydia IgA and/or IgG were associated with a high level of C3 but not other immunological and coagulatory parameters. CONCLUSION: Antibodies to C. trachomatis do not influence subsequent pregnancy outcome in patients with a history of recurrent miscarriage.
Authors:
Mayumi Sugiura-Ogasawara; Yasuhiko Ozaki; Tamao Nakanishi; Yoshiaki Kumamoto; Kaoru Suzumori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  53     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-25     Completed Date:  2005-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  50-3     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan. og.mym@med.nagoya-cu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / immunology*
Adult
Chlamydia Infections / immunology*
Chlamydia trachomatis / immunology
Female
Humans
Immunoglobulin A / immunology*
Immunoglobulin G / immunology*
Pregnancy
Pregnancy Outcome*
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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