Document Detail

Pregnancy outcome in nephrotic syndrome with mixed connective tissue disease.
MedLine Citation:
PMID:  11598404     Owner:  NLM     Status:  MEDLINE    
We describe two pregnancies of a young woman with mixed connective tissue disease. In June 1983, she was diagnosed as having Raynaud's phenomenon, arthralgia, and proteinuria. She then developed nephrotic syndrome. Methylprednisolone was initially prescribed at a large dose of 1 g/day which was slowly tapered to 5 mg/day. The proteinuria disappeared. During both pregnancies (the first beginning in December 1988 and the second in May 1992), the patient was placed on a prednisolone maintenance dose (5 mg/day). Both neonates were born healthy at term with no complications. Continuing prednisolone may be useful in pregnant women, and aggressive treatment to prevent mixed connective tissue disease exacerbation may be appropriate during pregnancy.
Y Horita; S Tsunoda; T Inenaga; Y Kawano; H Ishibashi-Ueda; Y Chiba; S Takishita
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Nephron     Volume:  89     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-12     Completed Date:  2001-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  354-6     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Osaka, Japan.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use
Labor, Obstetric
Methylprednisolone / therapeutic use
Mixed Connective Tissue Disease / complications*,  prevention & control
Nephrotic Syndrome / etiology*,  prevention & control
Pregnancy Complications / physiopathology*,  therapy
Pregnancy Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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