Document Detail

Pregnancy outcome in HbSS-sickle cell disease in Lagos, Nigeria.
MedLine Citation:
PMID:  12083064     Owner:  NLM     Status:  MEDLINE    
A retrospective study of pregnancy outcome in 60 HbSS sickle cell disease patients, exclusively managed in accordance with standard management modality, as obtained in the obstetric Unit of the Lagos University Teaching Hospital (LUTH), was carried out over a 3-year period (1995-1997). The study shows an increase in the number HbSS patients seeking antenatal care in the LUTH. Although the patients maintained a stable haematological profile, all through pregnancy and delivery, as reflected by the booking, pre-delivery and post-delivery PCV of 23.2 +/- SD 4.6% and 23.6 +/- SD 4.5% respectively; pregnancy was complicated in 96.6% of cases (n = 58). Sickle cell crises of bone pain (41.4%), acute haemolysis with anaemia (34.4%); malaria (22.4%) and other systemic infections (22.4%) were the major causes of pregnancy complications. Antenatal and postpartum blood transfusion rates were 45.0% and 81.6% respectively. The perinatal and maternal mortality rates were 121 and 67/1000 respectively, while caesarean section rate was 43.2%. It is observed that while more patients with HbSS sickle cell disease are seeking antenatal care in the LUTH, with improved prognosis, pregnancy complications from sickle cell crisis, remain a major problem in the care of these patients.
C U Odum; R I Anorlu; S I Dim; T O Oyekan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  West African journal of medicine     Volume:  21     ISSN:  0189-160X     ISO Abbreviation:  West Afr J Med     Publication Date:    2002 Jan-Mar
Date Detail:
Created Date:  2002-06-25     Completed Date:  2002-07-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8301891     Medline TA:  West Afr J Med     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  19-23     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Nigeria.
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MeSH Terms
Anemia, Sickle Cell / complications*,  therapy
Blood Transfusion
Cesarean Section
Infant Mortality
Infant, Newborn
Maternal Mortality
Nigeria / epidemiology
Pregnancy Complications, Hematologic* / therapy
Pregnancy Outcome*
Prenatal Care
Retrospective Studies
Statistics, Nonparametric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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