Document Detail

Pregnancy outcome in 98 women exposed to diethylstilbestrol in utero, their mothers, and unexposed siblings.
MedLine Citation:
PMID:  7078877     Owner:  NLM     Status:  MEDLINE    
The reproductive capability and labor complications of 98 women exposed to diethylstilbestrol (DES) in utero were compared with those of 3 separate control groups. The controls consisted of 167 age-matched, normal women, 20 siblings not exposed to DES who had achieved pregnancy, and their mothers. Spontaneous abortion, ectopic pregnancy, incompetent cervix, and premature labor occurred significantly more often in the DES-exposed population than in the normal controls. The controls also achieved a higher percentage of desired pregnancies overall; this was statistically significant (89.6 versus 75.0%, P less than .001). When compared with their mothers, however, the DES-exposed population achieved a greater percentage of desired, viable pregnancies (75.6 versus 67.0%, P less than .001). The unexposed siblings of the DES women achieved a higher percentage of desired, viable pregnancies than did their exposed sisters (86.9 versus 73.6%, P = .274), but less than the normal population (86.9 versus 89.6%).
C E Mangan; L Borow; M M Burtnett-Rubin; V Egan; R L Giuntoli; J J Mikuta
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  59     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-07-22     Completed Date:  1982-07-22     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  315-9     Citation Subset:  AIM; IM    
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MeSH Terms
Abortion, Incomplete / chemically induced
Diethylstilbestrol / adverse effects*
Fetal Membranes, Premature Rupture / chemically induced
Infant, Newborn
Obstetric Labor, Premature / chemically induced
Pregnancy Complications / chemically induced*,  epidemiology
Pregnancy, Ectopic / chemically induced
Prenatal Exposure Delayed Effects*
Uterine Cervical Incompetence / chemically induced
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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