Document Detail

Pregnancy outcome of fetuses with trisomy 18 identified by prenatal sonography and chromosomal analysis in a perinatal center.
MedLine Citation:
PMID:  16652360     Owner:  NLM     Status:  MEDLINE    
To investigate the pregnancy outcome of fetuses affected with trisomy 18, we analyzed 63 cases diagnosed at our hospital from January 1993 to December 2004. Twenty-nine were males and 34 were females. Fifty-eight were prenatally diagnosed, and in 16 (27.6%) of them intrauterine fetal death (IUFD) occurred between 28 weeks and 41 weeks gestation (34.6 +/- 3.9 weeks, Mean +/- SD). Ten (17.2%) fetuses died during labor and their age ranged from 30 weeks to 40 weeks of gestation. The total number of cases ending in fetal demise was 26 (44.8%) and the mean gestational age at the time of fetal demise was 35.0 +/- 3.6 weeks (Mean +/- SD). All liveborn infants (n = 36) were born after 31 weeks gestation. In our study the preterm birth ratio for trisomy 18 is 34.8%, which is much higher than the ratio for the general population. Females are more likely than males to be long-term survivors. These data are helpful in the counseling of parents faced with the difficult decision of whether or not to continue a pregnancy with a fetus affected with trisomy 18.
Michiko Yamanaka; Takuya Setoyama; Youko Igarashi; Kenji Kurosawa; Yasufumi Itani; Sakae Hashimoto; Keisuke Saitoh; Miki Takei; Tomoo Hirabuki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of medical genetics. Part A     Volume:  140     ISSN:  1552-4825     ISO Abbreviation:  Am. J. Med. Genet. A     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-30     Completed Date:  2006-07-27     Revised Date:  2006-09-01    
Medline Journal Info:
Nlm Unique ID:  101235741     Medline TA:  Am J Med Genet A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1177-82     Citation Subset:  IM    
Copyright Information:
Copyright 2006 Wiley-Liss, Inc.
Department of Perinatal Care, Division of Obstetrics, Kanagawa Children's Medical Center, Mutsukawa, Yokohama City, Japan.
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MeSH Terms
Chromosomes, Human, Pair 18 / genetics*
Fetal Diseases / genetics*,  mortality
Gestational Age
Hospitals, Pediatric
Infant, Newborn
Perinatal Care / statistics & numerical data
Pregnancy Outcome*
Survival Rate
Trisomy / genetics*
Ultrasonography, Prenatal*
Erratum In:
Am J Med Genet A. 2006 Aug 15;140(16):1796

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