| Pregnancy outcome of fetuses with trisomy 18 identified by prenatal sonography and chromosomal analysis in a perinatal center. | |
| | |
MedLine Citation:
|
PMID: 16652360 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To investigate the pregnancy outcome of fetuses affected with trisomy 18, we analyzed 63 cases diagnosed at our hospital from January 1993 to December 2004. Twenty-nine were males and 34 were females. Fifty-eight were prenatally diagnosed, and in 16 (27.6%) of them intrauterine fetal death (IUFD) occurred between 28 weeks and 41 weeks gestation (34.6 +/- 3.9 weeks, Mean +/- SD). Ten (17.2%) fetuses died during labor and their age ranged from 30 weeks to 40 weeks of gestation. The total number of cases ending in fetal demise was 26 (44.8%) and the mean gestational age at the time of fetal demise was 35.0 +/- 3.6 weeks (Mean +/- SD). All liveborn infants (n = 36) were born after 31 weeks gestation. In our study the preterm birth ratio for trisomy 18 is 34.8%, which is much higher than the ratio for the general population. Females are more likely than males to be long-term survivors. These data are helpful in the counseling of parents faced with the difficult decision of whether or not to continue a pregnancy with a fetus affected with trisomy 18. |
| | |
Authors:
|
Michiko Yamanaka; Takuya Setoyama; Youko Igarashi; Kenji Kurosawa; Yasufumi Itani; Sakae Hashimoto; Keisuke Saitoh; Miki Takei; Tomoo Hirabuki |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of medical genetics. Part A Volume: 140 ISSN: 1552-4825 ISO Abbreviation: Am. J. Med. Genet. A Publication Date: 2006 Jun |
Date Detail:
|
Created Date: 2006-05-30 Completed Date: 2006-07-27 Revised Date: 2006-09-01 |
Medline Journal Info:
|
Nlm Unique ID: 101235741 Medline TA: Am J Med Genet A Country: United States |
Other Details:
|
Languages: eng Pagination: 1177-82 Citation Subset: IM |
Copyright Information:
|
Copyright 2006 Wiley-Liss, Inc. |
Affiliation:
|
Department of Perinatal Care, Division of Obstetrics, Kanagawa Children's Medical Center, Mutsukawa, Yokohama City, Japan. michikoy@yha.att.ne.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chromosomes, Human, Pair 18
/
genetics* Female Fetal Diseases / genetics*, mortality Gestational Age Hospitals, Pediatric Humans Infant, Newborn Japan Male Perinatal Care / statistics & numerical data Pregnancy Pregnancy Outcome* Survival Rate Trisomy / genetics* Ultrasonography, Prenatal* |
| Comments/Corrections | |
Erratum In:
|
Am J Med Genet A. 2006 Aug 15;140(16):1796 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intrachromosomal triplication 12p11.22-p12.3 and gonadal mosaicism of partial tetrasomy 12p.
Next Document: A population-based case-control study of isolated primary congenital glaucoma.