Document Detail


Pregnancy outcome of euploid fetuses with increased nuchal translucency: how bad is the news?
MedLine Citation:
PMID:  15914340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: The number of fetuses with an abnormal increased first trimester nuchal translucency (NT), but confirmed normal karyotype and anatomy is relatively small and therefore a challenge for prenatal counseling. Universal guidelines are still needed for a systematic work-up, how to decide on the rewarding cut-off for this policy as well as how to counsel patients with an increased NT but with euploid fetuses. The current review aims to address some of these issues. RESULTS: Eleven studies reporting on the pregnancy outcome of 2,128 euploid fetuses with increased NT (>or=3 mm or >or=95 centile) were retrieved by our previously reported literature search. 2.2-10.6% of the fetuses has miscarried and 0.5-15.8% ended in perinatal death. There was an overall rate of 0.5-13% neurodevelopmental problems, and 2-8% of the malformations were undiagnosed before birth, the most common being cardiac anomalies. Nevertheless, 70-90% fetuses had normal outcomes. CONCLUSION: For those euploid fetuses with increased NT>2 MoM or >or=1.5 mm delta NT we recommend a detailed two-step anomaly scan including midgestation fetal echocardiography. Maternal age as well as data on relevant family history and persistence of nuchal edema provides additional relevant information for counseling and planning pregnancy management.
Authors:
Ron Maymon; Zwi Weinraub; Arie Herman
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  33     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2005  
Date Detail:
Created Date:  2005-05-25     Completed Date:  2005-10-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  191-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. intposgr@post.tau.ac.il
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MeSH Terms
Descriptor/Qualifier:
Congenital Abnormalities / diagnosis,  epidemiology
Diseases in Twins / diagnosis,  epidemiology
Female
Fetal Diseases / diagnosis*,  epidemiology*,  genetics
Genetic Diseases, Inborn / diagnosis,  epidemiology
Humans
Infant, Newborn
Infant, Newborn, Diseases / diagnosis,  epidemiology
Nuchal Translucency Measurement / statistics & numerical data*
Pregnancy
Pregnancy Complications, Infectious / diagnosis,  epidemiology
Pregnancy Outcome / epidemiology*,  genetics
Pregnancy Trimester, First
Prenatal Care / methods
Prevalence

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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