| Pregnancy outcome of euploid fetuses with increased nuchal translucency: how bad is the news? | |
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MedLine Citation:
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PMID: 15914340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The number of fetuses with an abnormal increased first trimester nuchal translucency (NT), but confirmed normal karyotype and anatomy is relatively small and therefore a challenge for prenatal counseling. Universal guidelines are still needed for a systematic work-up, how to decide on the rewarding cut-off for this policy as well as how to counsel patients with an increased NT but with euploid fetuses. The current review aims to address some of these issues. RESULTS: Eleven studies reporting on the pregnancy outcome of 2,128 euploid fetuses with increased NT (>or=3 mm or >or=95 centile) were retrieved by our previously reported literature search. 2.2-10.6% of the fetuses has miscarried and 0.5-15.8% ended in perinatal death. There was an overall rate of 0.5-13% neurodevelopmental problems, and 2-8% of the malformations were undiagnosed before birth, the most common being cardiac anomalies. Nevertheless, 70-90% fetuses had normal outcomes. CONCLUSION: For those euploid fetuses with increased NT>2 MoM or >or=1.5 mm delta NT we recommend a detailed two-step anomaly scan including midgestation fetal echocardiography. Maternal age as well as data on relevant family history and persistence of nuchal edema provides additional relevant information for counseling and planning pregnancy management. |
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Authors:
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Ron Maymon; Zwi Weinraub; Arie Herman |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 33 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 2005 |
Date Detail:
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Created Date: 2005-05-25 Completed Date: 2005-10-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
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Languages: eng Pagination: 191-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. intposgr@post.tau.ac.il |
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| MeSH Terms | |
Descriptor/Qualifier:
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Congenital Abnormalities
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diagnosis,
epidemiology Diseases in Twins / diagnosis, epidemiology Female Fetal Diseases / diagnosis*, epidemiology*, genetics Genetic Diseases, Inborn / diagnosis, epidemiology Humans Infant, Newborn Infant, Newborn, Diseases / diagnosis, epidemiology Nuchal Translucency Measurement / statistics & numerical data* Pregnancy Pregnancy Complications, Infectious / diagnosis, epidemiology Pregnancy Outcome / epidemiology*, genetics Pregnancy Trimester, First Prenatal Care / methods Prevalence |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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