Document Detail


Pregnancy outcome after the use of an aromatase inhibitor for ovarian stimulation.
MedLine Citation:
PMID:  15695975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study was undertaken to report the outcome of pregnancies achieved after ovarian stimulation, including the use of the aromatase inhibitor, letrozole, for ovarian stimulation. STUDY DESIGN: A cohort study comparing the outcome of pregnancies achieved after letrozole and other ovarian stimulation treatments with a control group of pregnancies spontaneously conceived without ovarian stimulation. RESULTS: In 3 tertiary referral centers, there were 394 pregnancy cycles in 345 infertile couples (63 pregnancies with 2.5 mg of letrozole alone or with gonadotropins, 70 pregnancies with 5.0 mg of letrozole, 113 pregnancies with clomiphene alone or with gonadotropins, 110 pregnancies with gonadotropins alone, and 38 pregnancies achieved without ovarian stimulation). Pregnancies conceived after letrozole treatments were associated with similar miscarriage and ectopic pregnancy rates compared with all other groups. In addition, letrozole use was associated with a significantly lower rate of multiple gestation compared with clomiphene citrate. CONCLUSION: The favorable pregnancy outcome and low multiple gestation rate of aromatase inhibitors for ovarian stimulation is encouraging for the development of these agents as first-line ovulation induction agents.
Authors:
Mohamed F Mitwally; Marinko M Biljan; Robert F Casper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  192     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-07     Completed Date:  2005-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  381-6     Citation Subset:  AIM; IM    
Affiliation:
Reproductive Sciences Division, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / epidemiology
Aromatase Inhibitors / pharmacology*
Cohort Studies
Female
Humans
Nitriles / pharmacology*
Ovulation Induction*
Pregnancy
Pregnancy Outcome*
Pregnancy Rate
Pregnancy, Multiple
Triazoles / pharmacology*
Chemical
Reg. No./Substance:
0/Aromatase Inhibitors; 0/Nitriles; 0/Triazoles; 112809-51-5/letrozole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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