| Pregnancy outcome after the use of an aromatase inhibitor for ovarian stimulation. | |
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MedLine Citation:
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PMID: 15695975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study was undertaken to report the outcome of pregnancies achieved after ovarian stimulation, including the use of the aromatase inhibitor, letrozole, for ovarian stimulation. STUDY DESIGN: A cohort study comparing the outcome of pregnancies achieved after letrozole and other ovarian stimulation treatments with a control group of pregnancies spontaneously conceived without ovarian stimulation. RESULTS: In 3 tertiary referral centers, there were 394 pregnancy cycles in 345 infertile couples (63 pregnancies with 2.5 mg of letrozole alone or with gonadotropins, 70 pregnancies with 5.0 mg of letrozole, 113 pregnancies with clomiphene alone or with gonadotropins, 110 pregnancies with gonadotropins alone, and 38 pregnancies achieved without ovarian stimulation). Pregnancies conceived after letrozole treatments were associated with similar miscarriage and ectopic pregnancy rates compared with all other groups. In addition, letrozole use was associated with a significantly lower rate of multiple gestation compared with clomiphene citrate. CONCLUSION: The favorable pregnancy outcome and low multiple gestation rate of aromatase inhibitors for ovarian stimulation is encouraging for the development of these agents as first-line ovulation induction agents. |
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Authors:
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Mohamed F Mitwally; Marinko M Biljan; Robert F Casper |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 192 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-02-07 Completed Date: 2005-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 381-6 Citation Subset: AIM; IM |
Affiliation:
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Reproductive Sciences Division, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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epidemiology Aromatase Inhibitors / pharmacology* Cohort Studies Female Humans Nitriles / pharmacology* Ovulation Induction* Pregnancy Pregnancy Outcome* Pregnancy Rate Pregnancy, Multiple Triazoles / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Aromatase Inhibitors; 0/Nitriles; 0/Triazoles; 112809-51-5/letrozole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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