| Pregnancy outcome after treatment with the ergot derivative, cabergoline. | |
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MedLine Citation:
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PMID: 8829257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The goal of this article is to assess the reproductive safety of cabergoline, a new ergot derivative proposed in hyperprolactinemic disorders. Investigated in different animal species, the drug showed no teratogenic or embryotoxic effects on rabbits. Considering the dose envisaged for humans, large safety margins exist. Our sample consists of 226 pregnancies occuring in 205 women. Follow-up is available for 204. There were 24 miscarriages and three abortions induced because of major malformations (one Down syndrome in a 42-year-old woman, one limb-body wall complex, one hydrocephalus). Two of the 148 single liveborn infants had significant malformations: one megaureter, one scaphocephaly. This series shows no increase in miscarriage rate, a distribution of birthweights and sex ratio within the expected range, and no increased rate of congenital malformations. Follow-up of babies, limited to 107 cases, thus far indicates normal physical and mental development. |
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Authors:
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E Robert; L Musatti; G Piscitelli; C I Ferrari |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 10 ISSN: 0890-6238 ISO Abbreviation: Reprod. Toxicol. Publication Date: 1996 Jul-Aug |
Date Detail:
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Created Date: 1997-01-09 Completed Date: 1997-01-09 Revised Date: 2013-05-28 |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 333-7 Citation Subset: IM |
Affiliation:
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Institut Européen des Génomutations, Lyon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology* Adult Birth Weight Dopamine Agonists / adverse effects*, therapeutic use Ergolines / adverse effects*, therapeutic use Female Follow-Up Studies Humans Hyperprolactinemia / drug therapy Italy Pregnancy Pregnancy Outcome |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agonists; 0/Ergolines; LL60K9J05T/cabergoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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