Document Detail

Pregnancy outcome after preimplantation genetic diagnosis in an affected couple with X-linked adrenoleukodystrophy.
MedLine Citation:
PMID:  18394607     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To achieve a pregnancy free of X-linked adrenoleukodystrophy (X-ALD) by intracytoplasmic sperm injection (ICSI) and preimplantation genetic diagnosis (PGD). DESIGN: Case report. SETTING: Clínica FIV Recoletos, a private IVF center. PATIENT(S): A couple in which the man had X-ALD. INTERVENTION(S): The ICSI protocol and PGD of the obtained embryos. MAIN OUTCOME MEASURE(S): Blastomeres were analyzed by fluorescence in situ hybridization using sex selection techniques. Embryos were transferred and pregnancy was diagnosed by hCG analysis and ultrasonographic examination. RESULT(S): Ten embryos were obtained by ICSI. A biopsy was taken from eight embryos to perform PGD and two male embryos were transferred resulting in a twin pregnancy. CONCLUSION(S): This is the first registered gestation in which PGD has been used to prevent X-ALD transmission.
Miriam Iglesias; Patricia Ceballos; Carles Giménez; Maria Isabel García-Nebreda; Raquel Domínguez; Alberto García-Enguídanos
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-04-03
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-10     Completed Date:  2008-12-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2010.e1-3     Citation Subset:  IM    
Department of In Vitro Fertilization, Clínica FIV Recoletos, Ciudad Real, Spain.
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MeSH Terms
Adrenoleukodystrophy / diagnosis*,  genetics
Chromosomes, Human, Pair 18*
Chromosomes, Human, X*
Chromosomes, Human, Y*
Embryo Transfer
Genetic Testing*
In Situ Hybridization, Fluorescence
Pregnancy, Multiple
Preimplantation Diagnosis*
Sex Determination (Analysis)
Sex Preselection
Sperm Injections, Intracytoplasmic*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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