| Pregnancy outcome after preimplantation genetic diagnosis in an affected couple with X-linked adrenoleukodystrophy. | |
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MedLine Citation:
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PMID: 18394607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To achieve a pregnancy free of X-linked adrenoleukodystrophy (X-ALD) by intracytoplasmic sperm injection (ICSI) and preimplantation genetic diagnosis (PGD). DESIGN: Case report. SETTING: Clínica FIV Recoletos, a private IVF center. PATIENT(S): A couple in which the man had X-ALD. INTERVENTION(S): The ICSI protocol and PGD of the obtained embryos. MAIN OUTCOME MEASURE(S): Blastomeres were analyzed by fluorescence in situ hybridization using sex selection techniques. Embryos were transferred and pregnancy was diagnosed by hCG analysis and ultrasonographic examination. RESULT(S): Ten embryos were obtained by ICSI. A biopsy was taken from eight embryos to perform PGD and two male embryos were transferred resulting in a twin pregnancy. CONCLUSION(S): This is the first registered gestation in which PGD has been used to prevent X-ALD transmission. |
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Authors:
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Miriam Iglesias; Patricia Ceballos; Carles Giménez; Maria Isabel García-Nebreda; Raquel Domínguez; Alberto García-Enguídanos |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-04-03 |
Journal Detail:
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Title: Fertility and sterility Volume: 90 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2008-12-10 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2010.e1-3 Citation Subset: IM |
Affiliation:
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Department of In Vitro Fertilization, Clínica FIV Recoletos, Ciudad Real, Spain. miriamen1@yahoo.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenoleukodystrophy
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diagnosis*,
genetics Adult Chromosomes, Human, Pair 18* Chromosomes, Human, X* Chromosomes, Human, Y* Embryo Transfer Female Genetic Testing* Humans In Situ Hybridization, Fluorescence Male Pregnancy Pregnancy, Multiple Preimplantation Diagnosis* Sex Determination (Analysis) Sex Preselection Sperm Injections, Intracytoplasmic* Twins Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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