| Pregnancy outcome after in utero exposure to colchicine. | |
| | |
MedLine Citation:
|
PMID: 20579964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: We sought to examine the fetal safety of colchicine. STUDY DESIGN: This was a prospective observational comparative cohort study regarding colchicine exposure during pregnancy including contacts to 2 Teratology Information Services in Israel from 1994 through 2006. RESULTS: In all, 238 colchicine-exposed pregnancies (97.0% first trimester) and 964 pregnancies with nonteratogenic exposure were followed up. Treatment indications were: familial Mediterranean fever (87.3%), Behçet disease (7.5%), or other (5.2%). The rate of major congenital anomalies was comparable between the groups (10/221 [4.5%] vs 35/908 [3.9%]; P = .648). There were no cytogenetic anomalies in the colchicine group. The median gestational age at delivery was earlier (39 [38-40] vs 40 [38-41] weeks; P < .001), the rate of preterm deliveries was higher (32/214 [15.0%] vs 51/867 [5.9%]; P < .001), and the median birthweight was lower (3000 [2688-3300] vs 3300 [2900-3600] g; P < .001) in the colchicine group. CONCLUSION: The present study suggests that colchicine does not appear to be a major human teratogen, and, probably, has no cytogenetic effect. |
| | |
Authors:
|
Orna Diav-Citrin; Svetlana Shechtman; Vardit Schwartz; Meytal Avgil-Tsadok; Victoriya Finkel-Pekarsky; Rebecka Wajnberg; Judy Arnon; Matitiahu Berkovitch; Asher Ornoy |
Related Documents
:
|
9277644 - Transvaginal ultrasound in the prediction of preterm delivery: singleton and twin gesta... 11146074 - Loop electrosurgical excision procedure of the cervix and time of delivery in subsequen... 7830304 - Active management of preterm labour and preterm prelabour rupture of membranes. 2712924 - The wider perinatal significance of the australian in vitro fertilization data collecti... 15465524 - Fecal androgens of bison bulls during the rut. 8513624 - Maternal, placental, and fetal pathophysiology of cocaine exposure during pregnancy. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-01 |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 203 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-27 Completed Date: 2010-08-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 144.e1-6 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright (c) 2010 Mosby, Inc. All rights reserved. |
Affiliation:
|
Israeli Teratology Information Service and Israel Ministry of Health, Jerusalem, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abnormalities, Drug-Induced
/
diagnosis*,
epidemiology* Adult Behcet Syndrome / drug therapy Birth Weight Cohort Studies Colchicine / adverse effects*, therapeutic use Drug Toxicity Familial Mediterranean Fever / diagnosis, drug therapy Female Fetus / drug effects* Follow-Up Studies Humans Israel Maternal Exposure / adverse effects* Maternal-Fetal Exchange / drug effects Obstetric Labor, Premature Pregnancy Pregnancy Outcome* Pregnancy Trimester, First Prenatal Exposure Delayed Effects / chemically induced* Probability Prospective Studies Risk Assessment Statistics, Nonparametric Teratogens |
| Chemical | |
Reg. No./Substance:
|
0/Teratogens; 64-86-8/Colchicine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: To the editors.
Next Document: Time for improved standards for studies of home birth.