Document Detail


Pregnancy outcome after in utero exposure to colchicine.
MedLine Citation:
PMID:  20579964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We sought to examine the fetal safety of colchicine. STUDY DESIGN: This was a prospective observational comparative cohort study regarding colchicine exposure during pregnancy including contacts to 2 Teratology Information Services in Israel from 1994 through 2006. RESULTS: In all, 238 colchicine-exposed pregnancies (97.0% first trimester) and 964 pregnancies with nonteratogenic exposure were followed up. Treatment indications were: familial Mediterranean fever (87.3%), Behçet disease (7.5%), or other (5.2%). The rate of major congenital anomalies was comparable between the groups (10/221 [4.5%] vs 35/908 [3.9%]; P = .648). There were no cytogenetic anomalies in the colchicine group. The median gestational age at delivery was earlier (39 [38-40] vs 40 [38-41] weeks; P < .001), the rate of preterm deliveries was higher (32/214 [15.0%] vs 51/867 [5.9%]; P < .001), and the median birthweight was lower (3000 [2688-3300] vs 3300 [2900-3600] g; P < .001) in the colchicine group. CONCLUSION: The present study suggests that colchicine does not appear to be a major human teratogen, and, probably, has no cytogenetic effect.
Authors:
Orna Diav-Citrin; Svetlana Shechtman; Vardit Schwartz; Meytal Avgil-Tsadok; Victoriya Finkel-Pekarsky; Rebecka Wajnberg; Judy Arnon; Matitiahu Berkovitch; Asher Ornoy
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-01
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  203     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  144.e1-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 Mosby, Inc. All rights reserved.
Affiliation:
Israeli Teratology Information Service and Israel Ministry of Health, Jerusalem, Israel.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / diagnosis*,  epidemiology*
Adult
Behcet Syndrome / drug therapy
Birth Weight
Cohort Studies
Colchicine / adverse effects*,  therapeutic use
Drug Toxicity
Familial Mediterranean Fever / diagnosis,  drug therapy
Female
Fetus / drug effects*
Follow-Up Studies
Humans
Israel
Maternal Exposure / adverse effects*
Maternal-Fetal Exchange / drug effects
Obstetric Labor, Premature
Pregnancy
Pregnancy Outcome*
Pregnancy Trimester, First
Prenatal Exposure Delayed Effects / chemically induced*
Probability
Prospective Studies
Risk Assessment
Statistics, Nonparametric
Teratogens
Chemical
Reg. No./Substance:
0/Teratogens; 64-86-8/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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