Document Detail


Pregnancy outcome after exposure to the probiotic Lactobacillus in early pregnancy.
MedLine Citation:
PMID:  22369393     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The present study prospectively assessed pregnancy outcome of women taking probiotics during the periconceptional period. A group of 104 women who had taken Lactobacillus in early pregnancy and 200 age- and parity-matched control pregnant women exposed to non-teratogenic agents were also recruited into the study and followed-up prospectively. Median gestational age of women exposed to Lactobacillus was 5.2 (range: 1.9-17.6) weeks. Exposure was at a mean dose of 510 mg/day for a median of 4.0 days (range: 1-90 days). In the exposed group, pregnancy outcomes included 96 live births and eight spontaneous abortions versus 187 live births and 21 spontaneous abortions in the non-exposed group. There was no statistical difference in adverse pregnancy outcomes, including the number of spontaneous abortions, pre-term births as well as a low birth weight between the two groups (p > 0.05). In the exposed group, there were two (2.1%) major congenital malformations in comparison with five (2.7%) in the comparison group (p = 0.7). In conclusion, no association was identified between ingestion of Lactobacillus in early pregnancy for a limited period of time and adverse pregnancy outcomes. However, rare pregnancy outcomes may have been missed due to the limited sample size included in the study.
Authors:
J E Lee; J Y Han; J S Choi; H K Ahn; S W Lee; M H Kim; H M Ryu; J H Yang; A A Nava-Ocampo; G Koren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  32     ISSN:  1364-6893     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-02-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  227-9     Citation Subset:  IM    
Affiliation:
The Korean Motherisk Program.
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