Document Detail

Pregnancy outcome after cervical conisation: a retrospective cohort study in the Leuven University Hospital.
MedLine Citation:
PMID:  19943824     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess pregnancy outcome after conisation. DESIGN: Retrospective cohort study. SETTING: Belgium, data from a university hospital. POPULATION: Fifty-five pregnancies in 34 women after conisation, and 55 pregnancies in 54 women without a history of conisation or cervical intraepithelial neoplasia (CIN). METHODS: Hospital data were reviewed and questionnaires were collected from 599 women who had a conisation in a 5-year period, among whom subsequent pregnancies were identified. The control group consisted of matched pregnancies of women without a history of conisation. MAIN OUTCOME MEASURES: Gestational age at delivery, neonatal biometry, neonatal condition at birth. RESULTS: Numbers of sexual partners (4.6 +/- 3.4 SD versus 2.5 +/- 2.5 SD) and ex-smokers were significantly higher in the study group compared with the control group. Gestational age at delivery (266 +/- 2 days versus 274 +/- 9 days), neonatal head circumference (33.9 +/- 2.5 cm, versus 34.6 +/- 2.5 cm) and birthweight (3088 +/- 754 g versus 3381 +/- 430 g) were significantly lower in the study group compared with the control group. Numbers of preterm [<37 weeks; 14/55 (25%) versus 2/55 (4%); P = 0.002] and severe preterm (<34 weeks; 6/55 (11%) versus 0/55 (0%); P = 0.031] deliveries in the study group were significantly higher. There were no cases of perinatal mortality. CONCLUSIONS: Conisation affects obstetrical outcome after conisation for CIN. Babies tend to be born earlier and are smaller. It is not clear whether this is related to the procedure or to factors linked with CIN.
A van de Vijver; W Poppe; J Verguts; M Arbyn
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Publication Detail:
Type:  Journal Article     Date:  2009-11-26
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  117     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-18     Completed Date:  2010-03-31     Revised Date:  2010-07-08    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  268-73     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, Hospital Sint-Lucas, Brugge, Belgium.
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MeSH Terms
Birth Weight
Cervical Intraepithelial Neoplasia / pathology,  surgery*
Conization / adverse effects*
Gestational Age
Head / anatomy & histology
Infant, Newborn
Obstetric Labor, Premature / etiology*
Pregnancy Outcome
Retrospective Studies
Sexual Behavior / statistics & numerical data
Uterine Cervical Neoplasms / pathology,  surgery*
Comment In:
BJOG. 2010 Aug;117(9):1159-61; author replies 1161-1162   [PMID:  20604780 ]
BJOG. 2010 Aug;117(9):1158; author replies 1158-9   [PMID:  20604778 ]
BJOG. 2010 Feb;117(3):243-4   [PMID:  20078585 ]

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