Document Detail


Pregnancy and obstetrical outcomes in pseudoxanthoma elasticum.
MedLine Citation:
PMID:  15541079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pseudoxanthoma elasticum (PXE) is a genetic multisystem disorder characterized by calcified dystrophic elastic fibres in skin, retina and arteries. Much of the earlier literature on pregnancy in PXE contained reports of severe complications, leading some healthcare providers to advise women with PXE against becoming pregnant and some women with PXE to avoid pregnancy. OBJECTIVES: To evaluate the obstetrical outcomes and the incidence of pregnancy complications in women with PXE and to determine if pregnancy is associated with an adverse effect on the course of the disease. METHODS: Women with PXE (n = 407) answered detailed questionnaires regarding reproductive history and pregnancy as well as the course of their disease. The frequency of reported pregnancy outcomes and complications was determined. Severity indices for the major clinical manifestations of PXE were developed and correlated with gravidity of affected women aged 40 years or over. RESULTS: Among the 306 respondents with PXE who had ever been pregnant, there were 795 pregnancies. Of these, 83% ended in live births and 1% in stillbirth. The median birth weight was within the normal range and the incidence of low birth weight for gestation was low. Hypertension occurred in 10% of pregnancies, gastric bleeding and retinal complications in < 1%, and 12% of pregnancies were associated with worsening of skin manifestations. There was no effect of gravidity and clinical severity on cutaneous (P = 0.07), ocular (P = 0.59) or cardiac (P = 0.42) manifestations of PXE in women aged 40+ years, nor did ever having been pregnant adversely affect these clinical severity indices. Of the 101 women who had never been pregnant, 17% made the decision because they were advised against becoming pregnant by a healthcare professional and 11% did not become pregnant because they feared an adverse outcome either in their pregnancy or disease. CONCLUSIONS: PXE is not associated with markedly increased fetal loss or adverse reproductive outcomes. The incidence of gastric bleeding, although probably higher than in the unaffected population, is much lower than previously reported, and retinal complications are uncommon. Although a few pregnancies were associated with worsening of skin manifestations, there was no correlation of either gravidity or ever having been pregnant with ultimate severity of skin, ocular or cardiovascular manifestations. There is no basis for advising women with PXE to avoid becoming pregnant, and most pregnancies in PXE are uncomplicated.
Authors:
L Bercovitch; T Leroux; S Terry; M A Weinstock
Related Documents :
16441949 - Developmental programming of health and disease.
16715249 - Pregnancy and delivery in patients with enterostomy due to anorectal complications from...
19844719 - Intravenous immunoglobulin treatment for pregnancy-associated dermatomyositis.
8371209 - Adult onset still's disease and pregnancy.
18215709 - Reproductive issues for adults with autosomal dominant polycystic kidney disease.
10763729 - Histological appearances in post-partum de quervain's disease.
2735369 - Safety and use of autologous blood donation during the third trimester of pregnancy.
8322369 - Stage-specific effects of cadmium on preimplantation embryo development and implantatio...
18208949 - Trastuzumab treatment for breast cancer during pregnancy.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  151     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-15     Completed Date:  2005-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1011-8     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Brown Medical School, Providence, RI, USA. lionel_bercovitch@brown.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Birth Weight
Databases, Factual
Female
Gravidity
Humans
Incidence
Infant, Newborn
Pregnancy
Pregnancy Complications* / epidemiology
Pregnancy Complications, Cardiovascular / epidemiology
Pregnancy Outcome
Prognosis
Pseudoxanthoma Elasticum / complications*
Questionnaires
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Development of a novel ELISA system for detection of anti-BP180 IgG and characterization of autoanti...
Next Document:  Rapid healing of intractable diabetic foot ulcers with exposed bones following a novel therapy of ex...