Document Detail

Pregnancy and multiple sclerosis.
MedLine Citation:
PMID:  2461576     Owner:  NLM     Status:  MEDLINE    
MS is an unpredictable, potentially disabling condition that occurs most commonly in women of reproductive age. The decision to have a baby after this diagnosis is a difficult and very personal one. Each couple considering a family deserves preconception counseling with accurate information and support to facilitate an informed decision. Consistently, studies have found that pregnancy is a period of safety from worsening of MS but that exacerbation occurs at two to three times the expected rate after delivery. Gestational history does not seem to affect the ultimate prognosis of the disease. The decision to bear children then seems to depend first on the desire of the woman to have a family. Additional issues to consider for a woman with MS considering pregnancy are current physical impairment and support available from father, family, and friends. There is considerable evidence that some protective factor exists during pregnancy to cause the disease to be less active. Presumably, this is a soluble factor or factors that suppress the cellular immune system. This is of great potential scientific interest, since it may contribute to our understanding of MS and potentially lead to newer avenues of research and treatment.
K Birk; S C Smeltzer; R Rudick
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in neurology     Volume:  8     ISSN:  0271-8235     ISO Abbreviation:  Semin Neurol     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-12-27     Completed Date:  1988-12-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8111343     Medline TA:  Semin Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-13     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Genesee Hospital, Rochester, New York.
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MeSH Terms
Guinea Pigs
Multiple Sclerosis / complications*,  immunology,  psychology
Pregnancy Complications / immunology,  physiopathology*,  psychology
alpha-Fetoproteins / therapeutic use
Reg. No./Substance:

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