Document Detail

Pregnancy modulates the expression of beta-N-acetylhexosaminidase in rat serum and tissues.
MedLine Citation:
PMID:  1397486     Owner:  NLM     Status:  MEDLINE    
1. beta-N-Acetylhexosaminidases in maternal rat serum were separated by DEAE-cellulose chromatography and compared with those of adult rat serum. 2. In pregnant serum there is an increase of the isoenzymes which are entirely composed of beta-subunits (B and intermediate forms). 3. These alterations could be compared to those already described in human pregnancy. 4. The levels of beta-N-acetylhexosaminidase and the relative expression of alpha- and beta-subunits in normal and pregnant serum correlate with the above isoenzyme expression. 5. The increase of B and intermediate forms as well as the increase of specific activity during pregnancy was not peculiar to maternal serum but was also demonstrated in several foetal tissues and in maternal tissues, in which cases the beta-N-acetylhexosaminidase isoenzyme patterns closely resemble the foetal ones rather than those of the adult rat tissues. 6. These analogies strongly suggest that the expression of beta-subunit of beta-N-acetylhexosaminidase is regulated by hormones or other factors related to pregnancy.
C Emiliani; P Locci; L Marinucci; R Rossi; A Orlacchio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of biochemistry     Volume:  24     ISSN:  0020-711X     ISO Abbreviation:  Int. J. Biochem.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-11-20     Completed Date:  1992-11-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0250365     Medline TA:  Int J Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1599-605     Citation Subset:  IM    
Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università di Perugia, Italy.
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MeSH Terms
Chromatography, DEAE-Cellulose
Kidney / metabolism
Lung / metabolism
Myocardium / metabolism
Pregnancy, Animal / blood,  metabolism*
Spleen / metabolism
beta-N-Acetylhexosaminidases / blood,  metabolism*
Reg. No./Substance:

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