Document Detail

Pregnancy, microchimerism and autoimmunity: an update.
MedLine Citation:
PMID:  15485097     Owner:  NLM     Status:  MEDLINE    
The presence of a small population of cells or DNA in one individual that derives from another genetically distinct person is referred to as microchimerism; this process may occur in course of pregnancy from mother to fetus, and vice versa. The clinical similarities between some features of autoimmune diseases and the chronic graft versus host disease, the increased incidence of autoimmune diseases observed in women after childbearing age, and the long-term persistence of microchimerism have raised the hypothesis that microchimerism could be involved in the pathogenesis of autoimmune diseases. To assess the possible relationship between pregnancy and the incidence of systemic sclerosis we performed a hospital-based case-control study. Our results, indicating a reduced risk for systemic sclerosis in women who had been pregnant in comparison with women who had not, seem to indicate that pregnancy is not a risk factor for systemic sclerosis.
A E Turco; L M Bambara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lupus     Volume:  13     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2004  
Date Detail:
Created Date:  2004-10-15     Completed Date:  2004-12-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  659-60     Citation Subset:  IM    
Department of Mother and Child, Section of Genetics, The University of Verona School of Medicine, University Hospital, Verona, Italy.
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MeSH Terms
Autoimmune Diseases / genetics*,  immunology
Fetus / immunology
Graft vs Host Disease / genetics,  immunology
Immune Tolerance
Placental Circulation
Risk Factors
Scleroderma, Systemic / genetics,  immunology

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