Document Detail

Pregnancy loss and thrombophilia: the elusive link.
MedLine Citation:
PMID:  22449204     Owner:  NLM     Status:  Publisher    
Recurrent pregnancy loss (RPL) affects 1% pregnancies and is multi-factorial in origin. The role of the acquired thrombophilia antiphospholipid syndrome (APS) as a common and potentially treatable cause of RPL is well established but this is less so for inherited thrombophilia. In obstetric APS the combination of aspirin and heparin has improved outcomes. By analogy, the use of low molecular weight heparin (LMWH) has become commonplace in women with inherited thrombophilia and also those with unexplained miscarriage to help safeguard the pregnancy. This review will examine the pathophysiological role of thrombophilia in pregnancy loss, and the evidence for anticoagulant-based intervention. The limited data supporting the use of heparin for women with RPL and inherited thrombophilia suggests adoption of a more cautious and judicious approach in this setting.
Sarah A Bennett; Catherine N Bagot; Roopen Arya
Related Documents :
1534444 - Impact of histocompatibility antigens on pregnancy outcome.
18925884 - Pregnancy ifn-gamma responses to foetal alloantigens are altered by maternal allergy an...
686054 - Effects of dexamethasone on leukocyte counts in pregnant sheep and fetal lambs.
18213524 - Immunoregulation of fetal and anti-paternal immune responses.
25262424 - Perceived social support, self esteem, and pregnancy status among dominican adolescents.
25308204 - The frequency of acute atherosis in normal pregnancy and preterm labor, preeclampsia, s...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-26
Journal Detail:
Title:  British journal of haematology     Volume:  -     ISSN:  1365-2141     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
King's Thrombosis Centre, Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Small molecule screening platform for assessment of cardiovascular toxicity on adult zebrafish heart...
Next Document:  Addressing poverty through disease control programmes: examples from Tuberculosis control in India.