Document Detail


Pregnancy loss and autoantibodies against phospholipid-binding proteins.
MedLine Citation:
PMID:  9170477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the relationship between antibodies against beta 2-glycoprotein I or prothrombin and pregnancy losses in women with antiphospholipid antibodies. METHODS: Women with antiphospholipid antibodies, (lupus anticoagulant and/or anticardiolipin antibodies), with (n = 41) and without (n = 61) a history of pregnancy loss were evaluated. Thirty-one out of the forty-one patients with pregnancy loss had early miscarriages (at less than 13 weeks) and ten patients had late miscarriages. Immunoglobulin (Ig)-G and IgM anti-beta 2-glycoprotein I and anti-prothrombin antibodies were measured by an enzyme-linked immunosorbent assay method. RESULTS: A significant association between pregnancy loss and positive IgM anti-beta 2-glycoprotein I antibodies was found (odds ratio 2.6; 95% confidence interval 1.03, 6.6; P = .043). Women with late pregnancy loss had higher levels of both IgG and IgM anti-beta 2-glycoprotein I antibodies compared with controls (P < .05). There was a good correlation between anticardiolipin and anti-beta 2-glycoprotein I antibodies levels (IgG: r = 0.75; IgM: r = 0.73). In contrast, there was no correlation between the levels of anticardiolipin or anti-beta2-glycoprotein I antibodies and the levels of anti-prothrombin antibodies. Furthermore, the presence of anti-prothrombin antibodies was not associated with a history of pregnancy loss. CONCLUSION: The result of our study shows that there is a relationship between the presence of IgM anti-beta 2-glycoprotein I and previous miscarriages in women with anti-phospholipid antibodies.
Authors:
C R Falcón; M E Martinuzzo; R R Forastiero; G S Cerrato; L O Carreras
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  89     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-01     Completed Date:  1997-07-01     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  975-80     Citation Subset:  AIM; IM    
Affiliation:
Department of Hematology, Favaloro Foundation, Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / immunology*
Adult
Antibodies, Antiphospholipid / blood
Autoantibodies / blood*
Blood Proteins / immunology*
Confidence Intervals
Female
Glycoproteins / immunology*
Humans
Immunoglobulin G / blood
Immunoglobulin M / blood
Middle Aged
Odds Ratio
Pregnancy
Pregnancy Outcome
Prothrombin / immunology*
Retrospective Studies
beta 2-Glycoprotein I
Chemical
Reg. No./Substance:
0/Antibodies, Antiphospholipid; 0/Autoantibodies; 0/Blood Proteins; 0/Glycoproteins; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/beta 2-Glycoprotein I; 9001-26-7/Prothrombin

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