| Pregnancy loss and autoantibodies against phospholipid-binding proteins. | |
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MedLine Citation:
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PMID: 9170477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the relationship between antibodies against beta 2-glycoprotein I or prothrombin and pregnancy losses in women with antiphospholipid antibodies. METHODS: Women with antiphospholipid antibodies, (lupus anticoagulant and/or anticardiolipin antibodies), with (n = 41) and without (n = 61) a history of pregnancy loss were evaluated. Thirty-one out of the forty-one patients with pregnancy loss had early miscarriages (at less than 13 weeks) and ten patients had late miscarriages. Immunoglobulin (Ig)-G and IgM anti-beta 2-glycoprotein I and anti-prothrombin antibodies were measured by an enzyme-linked immunosorbent assay method. RESULTS: A significant association between pregnancy loss and positive IgM anti-beta 2-glycoprotein I antibodies was found (odds ratio 2.6; 95% confidence interval 1.03, 6.6; P = .043). Women with late pregnancy loss had higher levels of both IgG and IgM anti-beta 2-glycoprotein I antibodies compared with controls (P < .05). There was a good correlation between anticardiolipin and anti-beta 2-glycoprotein I antibodies levels (IgG: r = 0.75; IgM: r = 0.73). In contrast, there was no correlation between the levels of anticardiolipin or anti-beta2-glycoprotein I antibodies and the levels of anti-prothrombin antibodies. Furthermore, the presence of anti-prothrombin antibodies was not associated with a history of pregnancy loss. CONCLUSION: The result of our study shows that there is a relationship between the presence of IgM anti-beta 2-glycoprotein I and previous miscarriages in women with anti-phospholipid antibodies. |
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Authors:
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C R Falcón; M E Martinuzzo; R R Forastiero; G S Cerrato; L O Carreras |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 89 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-07-01 Completed Date: 1997-07-01 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 975-80 Citation Subset: AIM; IM |
Affiliation:
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Department of Hematology, Favaloro Foundation, Buenos Aires, Argentina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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immunology* Adult Antibodies, Antiphospholipid / blood Autoantibodies / blood* Blood Proteins / immunology* Confidence Intervals Female Glycoproteins / immunology* Humans Immunoglobulin G / blood Immunoglobulin M / blood Middle Aged Odds Ratio Pregnancy Pregnancy Outcome Prothrombin / immunology* Retrospective Studies beta 2-Glycoprotein I |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antiphospholipid; 0/Autoantibodies; 0/Blood Proteins; 0/Glycoproteins; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/beta 2-Glycoprotein I; 9001-26-7/Prothrombin |
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