| Pregnancy and live birth following the transfer of vitrified-warmed blastocysts derived from zona- and corona-cell-free oocytes. | |
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MedLine Citation:
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PMID: 20800550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study reports two clinical pregnancies and one live birth following the transfer of vitrified blastocysts developed from oocytes with neither zona pellucida nor corona cells. Two zona-free oocytes obtained from two patients of advanced maternal age undergoing minimal stimulation were normally fertilized after intracytoplasmic sperm injection. In case 1, all four blastomeres of the zona-free embryo were loosely associated and inserted back into ruptured zona on day 2. Zona-free embryo from case 2 had tight contacts between blastomeres and was cultured without zona. Both embryos derived from zona-free oocytes progressed to blastocyst stage and were cryopreserved by vitrification. When patients came back for a cryopreserved embryo transfer, both vitrified blastocysts survived warming. In case 1, transfer of a warmed blastocyst with reconstructed zona resulted in a clinical pregnancy that ended in a spontaneous abortion at 22 weeks. In case 2, live birth was achieved with a normal healthy baby (male) weighing 2381 g at 40 weeks' gestation. This report emphasizes the importance of maintenance of normal cell arrangement on the subsequent embryonic development for a zona-free oocyte. Zona-free oocytes may provide a valuable source of embryos for infertility patients, especially for those with a limited number of oocytes. |
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Authors:
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Yimin Shu; Wenlin Peng; John Zhang |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-05-10 |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 21 ISSN: 1472-6491 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: Netherlands |
Other Details:
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Languages: eng Pagination: 527-32 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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New Hope Fertility Center, 784 Park Avenue, New York City, NY 10021, USA; IVF Program, Stanford University Medical Center, Palo Alto, CA 94304, USA. shuyimin@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blastocyst / physiology* Cryopreservation / methods Embryo Transfer / methods* Female Humans Live Birth Male Maternal Age Oocytes / growth & development Pregnancy Semen Preservation Sperm Injections, Intracytoplasmic Vitrification Zona Pellucida / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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