| Pregnancy and lactation have anti-obesity and anti-diabetic effects in A(y)/a mice. | |
| | |
MedLine Citation:
|
PMID: 19785628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: Dominant 'yellow' mutation at the mouse agouti locus (A(y)) results in obesity. Pregnancy and lactation are characterized by large energy demand. The aim of this study was to investigate whether obesity would develop in pregnant and suckling A(y) mice. METHODS: Body weight and food intake in pregnancy, lactation, and after weaning, plasma leptin, insulin, corticosterone and blood glucose concentrations on days 7, 13 and 18 of pregnancy, days 1, 10, 21 and 80 postpartum, glucose and insulin tolerance on pregnancy days 7 and 18 were measured in C57Bl/6J mice of a/a (normal metabolism) and A(y)/a genotypes. The same parameters were also measured in age-matched virgin females. RESULTS: Virgin A(y)/a females exhibited hyperphagia, enhanced body weight, glucose intolerance and normal blood parameters at the mating age. With age, they developed obesity, hyperleptinaemia, hyperinsulinaemia and hyperglycaemia. Obesity did not develop in mated A(y)/a mice; during suckling, they had equal food intake and body weight as a/a mice. During pregnancy, glucose tolerance was enhanced in A(y)/a mice and became equal in both genotypes. In both genotypes, concentrations of hormones increased, and glucose decreased from pregnancy day 7 to day 18 and returned to normal values after parturition. A(y)/a mice did not differ from a/a in corticosterone, insulin and glucose levels during pregnancy and lactation, in leptin levels during suckling; however, A(y)/a mice had two times higher leptin levels than a/a during pregnancy. After weaning, A(y)/a mice began to eat and weigh more than a/a exhibiting normal metabolic parameters for 50 days. CONCLUSION: Pregnancy and lactation retard obesity and diabetes development in A(y) mice. |
| | |
Authors:
|
E N Makarova; T V Yakovleva; A Y Shevchenko; N M Bazhan |
Related Documents
:
|
16864868 - Changes in ovine maternal temperature, and serum cortisol and interleukin-6 concentrati... 16025218 - Calcium and bone metabolism during pregnancy and lactation. 1951778 - Is fetal acidosis in the human fetus maternogenic during labor? a reanalysis. 10386778 - The impact of mammalian reproduction on cancellous bone architecture. 19129708 - Percutaneous laser ablation of sacrococcygeal teratoma in a hydropic fetus with severe ... 9196448 - Time to pregnancy: a measure of reproductive function in either sex. asclepios project. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-24 |
Journal Detail:
|
Title: Acta physiologica (Oxford, England) Volume: 198 ISSN: 1748-1716 ISO Abbreviation: Acta Physiol (Oxf) Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-01-18 Completed Date: 2010-04-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101262545 Medline TA: Acta Physiol (Oxf) Country: England |
Other Details:
|
Languages: eng Pagination: 169-77 Citation Subset: IM |
Affiliation:
|
Institute of Cytology and Genetics, Siberian Division of Russian Academy of Science, Novosibirsk, Russia. enmakarova@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Animals Blood Glucose / analysis Body Weight / physiology* Breast Feeding Corticosterone / adverse effects, analogs & derivatives*, analysis Diabetes Mellitus / physiopathology* Female Glucose Intolerance Insulin Resistance / physiology Lactation / physiology* Leptin / blood* Mice Mice, Inbred C57BL Obesity / etiology* Pregnancy / blood, physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Leptin; 50-22-6/Corticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Experience-dependent plasticity in hypocretin/orexin neurones: re-setting arousal threshold.
Next Document: Systemic nitric oxide clamping in normal humans guided by total peripheral resistance.