Document Detail

Pregnancy interrupting effects of some bacterial toxins.
MedLine Citation:
PMID:  178014     Owner:  NLM     Status:  MEDLINE    
Embryotoxic properties of Shigella dysenteriae and Clostridium perfringens toxins, of E. coli endotoxin, V. cholerase and E. coli enterotoxins were compared in mice. E. coli endotoxin has embryotoxic effects at all stages of pregnancy. E. coli enterotoxin V. cholerae enterotoxin and Shigella dysenteriae toxin are most effective mainly at earlier stages of pregnancy. Clostridium perfringens toxin has no embryotoxic effect.
Pregnancy interrupting effects of some bacterial toxins were studied in mice. Embryotoxic properties of Shigella dysenteriae and Clostridium perfringens toxins, Escherichia coli endotoxin, Vibrio cholerae, and Escherichia coli interotoxins were compared up to Day 18 of pregnancy following injections on Day 6, 8, or 13 of pregnancy. Escherichia coli endotoxin caused embryotoxic effects in all stages of pregnancy while Escherichia coli enterotoxin, Vibrio cholerae enterotoxin, and Shigella dysenteriae toxin were most effective mainly at earlier stages of pregnancy. Histological studies revealed indirect embryotoxicity at later stages by placental damage. The main site of damage was the fetal side for Shigella dysenteriae toxin and the maternal side for Escherichia coli endotoxin, enterotoxin, and cholera toxin. Clostridium perfringens toxin had no embryonic effect.
T Sechser; J Vanĕcek; H Rasková; Z Jiricka; D Matĕjovská; V Matĕjovská
Related Documents :
25414264 - Maternal titers after adequate syphilotherapy during pregnancy.
21664674 - Comparing ethylene glycol with glycerol for cryopreservation of buffalo bull semen in e...
16601904 - Severe normotensive metabolic alkalosis in a 2-month-old boy with hyperekplexia.
1990224 - Antibacterial effects of fibrin glue-antibiotic mixtures.
15791664 - Prenatal diagnosis of megacystis-microcolon-intestinal hypoperistalsis syndrome: contri...
10601084 - The prognostic role of salpingoscopy in laparoscopic tubal surgery.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiologia Bohemoslovaca     Volume:  25     ISSN:  0369-9463     ISO Abbreviation:  Physiol Bohemoslov     Publication Date:  1976  
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0175317     Medline TA:  Physiol Bohemoslov     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM; J    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abortifacient Agents, Nonsteroidal
Clostridium perfringens
Embryo, Mammalian / drug effects
Endotoxins / pharmacology*
Escherichia coli
Pregnancy / drug effects*
Shigella dysenteriae
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Endotoxins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of adrenal glucocorticoids on beta-lipoprotein production by resected liver.
Next Document:  Aspects of the value of humoral antibodies in encephalomyelitis of neuroallergic origin