Document Detail

Pregnancy and inflammatory bowel disease: a prospective case-control study.
MedLine Citation:
PMID:  18293689     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Taking into account the relative confusion in the literature concerning the influence of pregnancy on the underlying inflammatory bowel disease (IBD) and vice versa, as well as the influence of drugs on the foetus and the gestation itself, we performed this prospective study, in order to further elucidate this interesting topic.
PATIENTS AND METHODS: Prospective follow-up study of 9 pregnant women with previously established IBD, 4 with ulcerative colitis (UC) and 5 with Crohn's disease (CD). Results were compared to those of 9 non-pregnant women with IBD with similar clinico-demographic characteristics (disease control group), and 18 healthy pregnancy women (healthy control group).
RESULTS: (a) Patients with IBD and gestation vs. healthy control group: Significantly impaired body weight in newborns from IBD mothers compared to healthy women (2530 +/- 961 g vs. 3242 +/- 582 g, P = 0.035) was found. Significantly more cases of therapeutic or spontaneous abortion and premature delivery in pregnant women with IBD compared to healthy pregnant women [5/ 9(56.6%) vs 1/18 (5.6%), P = 0.008] were also noticed. Concerning drug consumption, it was noticed that azathioprine was taken regularly in one case of spontaneous abortion and in one case of premature delivery. No significant differences concerning other parameters such as smoking habit and death of foetus were observed. (b) Patients with IBD and gestation vs. patients with IBD without gestation: No significant differences in the history of various parameters of the disease (number of operations, presence of fistulas), previous gestations, and course of the disease during the period of gestation were found. (c) Course of the disease six months after delivery: No significant differences between patients with IBD and pregnancy and disease control group were noticed.
CONCLUSION: It is concluded that gestation in women with IBD is accompanied by some unwanted events such as premature delivery, therapeutic or spontaneous abortion, and reduced newborn body weight. Clinicians must bear in mind the possibility of the appearance of some unwanted events in pregnant women with IBD during their gestation.
G Malgarinos; A Gikas; Evi Delicha; Asteria Stamataki; F Georgopoulos; A Papadimitriou; C Stanciu; J K Triantafillidis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i     Volume:  111     ISSN:  0048-7848     ISO Abbreviation:  Rev Med Chir Soc Med Nat Iasi     Publication Date:    2007 Jul-Sep
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-06-23     Revised Date:  2011-01-13    
Medline Journal Info:
Nlm Unique ID:  0413735     Medline TA:  Rev Med Chir Soc Med Nat Iasi     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  613-9     Citation Subset:  IM    
Saint Panteleimon General State Hospital Nikea, Department of Gastroenterology.
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MeSH Terms
Abortion, Spontaneous / chemically induced,  etiology*
Anti-Inflammatory Agents / adverse effects
Anti-Inflammatory Agents, Non-Steroidal / adverse effects
Antibodies, Monoclonal / adverse effects,  therapeutic use
Azathioprine / adverse effects
Case-Control Studies
Colitis, Ulcerative / complications
Crohn Disease / complications
Drug Therapy, Combination
Follow-Up Studies
Immunosuppressive Agents / adverse effects
Infant, Low Birth Weight*
Infant, Newborn
Inflammatory Bowel Diseases / complications*,  drug therapy
Mesalamine / adverse effects
Pregnancy Complications*
Pregnancy Outcome
Premature Birth / etiology*
Prospective Studies
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antibodies, Monoclonal; 0/Immunosuppressive Agents; 0/infliximab; 446-86-6/Azathioprine; 89-57-6/Mesalamine

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