| Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance. | |
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MedLine Citation:
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PMID: 20439708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A fetus is inherently antigenic to its mother and yet is not rejected. The T regulatory (Treg) subset of CD4(+) T cells can limit immune responses and has been implicated in maternal tolerance of the fetus. Using virgin inbred mice undergoing a first syngenic pregnancy, in which only the male fetuses are antigenic, we demonstrate a maternal splenocyte proliferative response to the CD4(+) T cell restricted epitope of the male antigen (H-Y) in proportion to the fetal antigen load. A portion of the maternal immune response to fetal antigens is Treg in nature. The bystander suppressive function of pregnancy-generated Tregs requires the presence of the fetal antigen, demonstrating their inherent antigen specificity. In vivo targeting of diphtheria toxin to kill Tregs leads to a lower fraction of live male offspring and a selective reduction in mass of the surviving males. Thus, Tregs generated in the context of pregnancy function in an antigen-specific manner to limit the maternal immune response to the fetus in a successful pregnancy. |
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Authors:
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Daniel A Kahn; David Baltimore |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-05-03 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-20 Completed Date: 2010-07-22 Revised Date: 2010-11-22 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 9299-304 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1740, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Cell Proliferation DNA Primers / genetics Epitopes / immunology Female H-Y Antigen / immunology* Histocompatibility, Maternal-Fetal / immunology* Immune Tolerance / immunology* Male Mice Mice, Inbred C57BL Polymerase Chain Reaction Pregnancy Spleen / cytology, immunology T-Lymphocytes, Regulatory / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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K12 HD001400/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Epitopes; 0/H-Y Antigen |
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