Document Detail

Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women.
MedLine Citation:
PMID:  21103027     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Preeclampsia (PE) is a major contributor to maternal and fetal mortality. The cause of preeclampsia remains unclear, but oxidative stress on the endothelium leading to endothelial dysfunction is said to be the root cause of the disease. The aim of this study was to measure and determine the plasma levels of key angiogenic factors in pregnancy as an indicator for the early onset of preeclampsia in pregnancy. Plasma levels of circulating a soluble fms like tyrosine kinase-1 (sFlt-1), an anti-angiogenic factor, vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), both pro-angiogenic factors were analyzed in normal pregnant Malaysian women (control group, n = 34), women with pregnant induced hypertension (PIH, n = 34) and women with preeclampsia (PE, n = 34) all at three gestational ages, 24-28 weeks (early pregnancy: EP), 32-36 weeks (late pregnancy: LP) and 6 weeks after delivery (postpartum: PN). The plasma levels of angiogenic factors were determined by ELISA. sFlt-1 levels were elevated in PIH and PE patients as compared to controls. PIGF and VEGF were significantly decreased in PIH and PE as compared to the controls. These results suggest that elevated concentration of sFlt-1 and suppressed levels of PIGF and VEGF may contribute to the development of hypertension in pregnancy which precedes preeclampsia.
Suseela Yelumalai; Sekaran Muniandy; Siti Zawiah Omar; Rajes Qvist
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Publication Detail:
Type:  Journal Article     Date:  2010-10-29
Journal Detail:
Title:  Journal of clinical biochemistry and nutrition     Volume:  47     ISSN:  1880-5086     ISO Abbreviation:  J Clin Biochem Nutr     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8700907     Medline TA:  J Clin Biochem Nutr     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  191-7     Citation Subset:  -    
Department of Obstretics & Gynaecology, University of Malaya Medical Center, University of Malaya, 50603 Kuala Lumpur, Malaysia.
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