Document Detail

Pregnancy induced hypertension: evidence for increased cell membrane permeability to sodium.
MedLine Citation:
PMID:  6412792     Owner:  NLM     Status:  MEDLINE    
In a cross sectional study of 137 women of childbearing age (16-40) the effects of normal pregnancy, hypertensive pregnancy, and oral contraceptives on red cell electrolyte content and sodium efflux rates were examined and the results compared with values in a control group of normotensive, non-pregnant women. Efflux rate constants were significantly increased in normotensive pregnancy and in women taking oral contraceptives. This was associated with a significant increase in sodium permeability in the contraceptive group. A much larger increase in sodium permeability and efflux rate constant was seen in the hypertensive group. The results permit a hypothesis that the hormonal changes induced by pregnancy and oral contraceptives increase membrane permeability to sodium and stimulate sodium efflux. The rise in blood pressure associated with use of oral contraceptives may have a similar aetiology to that occurring in pregnancy induced hypertension.
P L Weissberg; J Weaver; K L Woods; M J West; D G Beevers
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British medical journal (Clinical research ed.)     Volume:  287     ISSN:  0267-0623     ISO Abbreviation:  Br Med J (Clin Res Ed)     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8302911     Medline TA:  Br Med J (Clin Res Ed)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  709-11     Citation Subset:  AIM; IM    
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MeSH Terms
Cell Membrane Permeability / drug effects
Contraceptives, Oral / pharmacology
Cross-Sectional Studies
Erythrocyte Membrane / metabolism
Hypertension / blood*
Potassium / blood
Pregnancy Complications, Cardiovascular / blood*
Sodium / blood*
Reg. No./Substance:
0/Contraceptives, Oral; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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