Document Detail

Pregnancy-induced hemolytic anemia with a possible immune-related mechanism.
MedLine Citation:
PMID:  18239010     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pregnancy-induced hemolytic anemia is a rare maternal complication that occurs during pregnancy and resolves soon after delivery. The mechanism is unclear, and the disease is often referred to as unexplained hemolytic anemia associated with pregnancy. CASE: We report a case of life-threatening hemolytic anemia that occurred during pregnancy and resolved spontaneously soon after delivery. Direct and indirect Coombs test results were negative. Several possible causes were investigated, but all were ruled out. However, an increased immunoglobulin G level was observed in maternal red blood cells throughout pregnancy when the patient was severely anemic. The immunoglobulin G level decreased after delivery and was close to the control level on postpartum day 5. CONCLUSION: These observations suggest that the hemolytic anemia in this patient had an immune-related etiology.
Shinji Katsuragi; Hiroshi Sameshima; Mitsuhiro Omine; Tsuyomu Ikenoue
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  111     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-01     Completed Date:  2008-03-27     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  528-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Kiyotake-Cho, Miyazaki, Japan.
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MeSH Terms
Anemia, Hemolytic / blood*,  immunology*,  therapy
Immunoglobulin G / blood*
Pregnancy Complications, Hematologic / blood*,  immunology*,  therapy
Remission, Spontaneous
Reg. No./Substance:
0/Immunoglobulin G

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