| Pregnancy-induced changes in sheep uterine and carotid arteries. | |
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MedLine Citation:
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PMID: 2581458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To characterize the effects of pregnancy on vascular tissue, intact segments of the uterine and carotid arteries were removed from nonpregnant and near-term pregnant sheep. Pressure-diameter relations were measured on isolated segments under activated (122 mM K+, 10(-4) M phenylephrine) and passive (0.1 mM Ca2+, 10(-5) M iodoacetic acid) conditions. DNA and RNA were determined spectrophotometrically. Collagen, elastin, and water contents were also measured. Pregnancy had no effect on either the mechanics or the biochemical properties of the carotid artery. However, there was a marked increase in internal radius in the uterine artery with pregnancy (0.060 +/- 0.016 vs. 0.198 +/- 0.019 cm). Active tangential stress increased, as did passive stiffness of the uterine artery. The collagen fraction decreased during pregnancy (57.2 +/- 2.4 vs. 45.7 +/- 2.2%), while elastin and RNA remained unchanged. A small decrease in DNA produced a significant increase in the RNA-to-DNA ratio. These data suggest that, in pregnancy, the uterine artery selectively undergoes a characteristic hypertrophy of its vascular smooth muscle. |
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Authors:
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K K Griendling; E O Fuller; R H Cox |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 248 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1985 May |
Date Detail:
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Created Date: 1985-06-14 Completed Date: 1985-06-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H658-65 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carotid Arteries / physiology* Collagen / analysis DNA / analysis Elastin / analysis Female Iodoacetates / pharmacology Iodoacetic Acid Phenylephrine / pharmacology Pregnancy Pregnancy, Animal* Pressure RNA / analysis Sheep Uterus / blood supply* |
| Grant Support | |
ID/Acronym/Agency:
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HD-16899/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Iodoacetates; 59-42-7/Phenylephrine; 63231-63-0/RNA; 64-69-7/Iodoacetic Acid; 9007-34-5/Collagen; 9007-49-2/DNA; 9007-58-3/Elastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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