Document Detail


Pregnancy-induced changes in immune protection of the genital tract: defining normal.
MedLine Citation:
PMID:  23313311     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Both the state of pregnancy as well as disruption of vaginal flora and immune mediators may increase the risk of human immunodeficiency virus-1 acquisition. The objective of this study was to define immune changes in lower genital and systemic immunity associated with normal pregnancy.
STUDY DESIGN: This prospective cohort enrolled low-risk pregnant and nonpregnant women ages 18-35 years. Pregnant women at <14 weeks and nonpregnant women in follicular phase of the menstrual cycle were included. Cervical and vaginal fluid was collected. Concentrations of immune mediators were measured using enzyme-linked immunosorbent assay-based methods or multiplex immunoassay. Samples were inoculated onto various culture media allowing for growth of Lactobacillus species, Gardnerella vaginalis, Escherichia coli, Enterococcus species, anaerobic gram-negative rods, Candida, Staphylococcus aureus, Ureaplasma species, and Mycoplasma hominis. Concentrations of immune mediators and vaginal colonization frequencies were compared between the pregnant and nonpregnant groups.
RESULTS: Genital tract concentration of interleukin-1β was higher during pregnancy compared to nonpregnant participants. Serum C-reactive protein concentrations were higher in all trimesters of pregnancy. Concentrations of secretory leukocyte protease inhibitor did not differ between groups. Lactobacillus was more commonly isolated from vaginal cultures of nonpregnant participants (100% vs 70.2%, P = .02). Identification of Candida, G vaginalis, M hominis, and S aureus was common and not different between groups. Ureaplasma species was isolated from >60% pregnant participants.
CONCLUSION: The proinflammatory cytokine, interleukin-1β, as well as the systemic marker of inflammation, C-reactive protein, are increased during pregnancy. The impact of these proinflammatory changes during pregnancy deserves further study.
Authors:
Brenna L Anderson; Hector Mendez-Figueroa; Joshua D Dahlke; Christina Raker; Sharon L Hillier; Susan Cu-Uvin
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-10
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  208     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-27     Completed Date:  2013-06-17     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321.e1-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Mosby, Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
C-Reactive Protein / analysis
Cervix Uteri / immunology,  microbiology
Female
Humans
Interleukin-1beta / analysis*
Menstrual Cycle / blood,  immunology*
Pregnancy / immunology*
Prospective Studies
Vagina / immunology*,  microbiology*
Young Adult
Grant Support
ID/Acronym/Agency:
D43 TW000231/TW/FIC NIH HHS; K12 HD050108/HD/NICHD NIH HHS; K12HD050108/HD/NICHD NIH HHS; K23 HD062340/HD/NICHD NIH HHS; K23HD062340-01/HD/NICHD NIH HHS; K24 AI066884/AI/NIAID NIH HHS; K24AI066884/AI/NIAID NIH HHS; P30 AI042853/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Interleukin-1beta; 9007-41-4/C-Reactive Protein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Amniotic Fluid Induces Platelet-Neutrophil Aggregation and Neutrophil Activation.
Next Document:  Management Strategy In Pregnancies With Elevated Second-Trimester Maternal Serum Alpha-Fetoprotein B...