Document Detail


Pregnancy induced changes in Cox-1, Cox-2 and NOSIII vascular and renal expression.
MedLine Citation:
PMID:  15633603     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to establish if there is a mutual regulation between COX and NOS in vascular and renal tissue during pregnancy, we measured the protein expression of COX-1, COX-2 and NOSIII by Western blot comparing the thoracic and abdominal aorta and the renal cortex and medulla of non pregnant and pregnant (21st day) Wistar rats. We found there was no difference in the quantity of protein of any of the two isoforms of COX between the two segments of the aorta of non pregnant animals while an increased expression of both COX-1 And COX-2 was found in the abdominal compared to the thoracic segment of the pregnant rats. An increased expression of NOS III was found in the abdominal segment of the aorta form pregnant rats. No changes were found between pregnant and no pregnant animals in the expression of COX-1 and COX-2 in the renal cortex or medulla while an increased expression of NOS III was found in the cortex from pregnant compared to non pregnant animals. These results suggest the influence of pregnancy is not homogeneous along the aorta and also that a balance between prostaglandins and nitric oxide is responsible of the blunted vascular reactivity during pregnancy in the rat.
Authors:
Rosa A Bobadilla; Ismael Bracho; Victor M Pérez Alvarez; Liliana Anguiano; Pedro López
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the Western Pharmacology Society     Volume:  47     ISSN:  0083-8969     ISO Abbreviation:  Proc. West. Pharmacol. Soc.     Publication Date:  2004  
Date Detail:
Created Date:  2005-01-06     Completed Date:  2005-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505899     Medline TA:  Proc West Pharmacol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-7     Citation Subset:  IM    
Affiliation:
Departamento de Fisiología y Farmacología, Escuela Superior de Medicina del IPN, Plan de San Luis y Díaz Mirón, Casco de Santo Tomás, México 11340 DF. rabobadilla@terra.com.mx
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Abdominal / enzymology
Aorta, Thoracic / enzymology
Blood Vessels / enzymology*
Cyclooxygenase 1
Cyclooxygenase 2
Female
Gene Expression Regulation, Enzymologic
Isoenzymes / biosynthesis*
Kidney / enzymology*
Kidney Cortex / enzymology
Kidney Medulla / metabolism
Membrane Proteins
Nitric Oxide Synthase / biosynthesis*
Nitric Oxide Synthase Type III
Pregnancy
Pregnancy, Animal / metabolism*
Prostaglandin-Endoperoxide Synthases / biosynthesis*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Isoenzymes; 0/Membrane Proteins; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 1.14.13.39/Nos3 protein, rat; EC 1.14.99.1/Cyclooxygenase 1; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases; EC 1.14.99.1/Ptgs1 protein, rat

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