| Pregnancy-induced adaptation in the neuroendocrine control of prolactin secretion. | |
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MedLine Citation:
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PMID: 18266946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During pregnancy, neuroendocrine control of prolactin secretion is markedly altered to allow a state of hyperprolactinaemia to develop. Prolactin secretion is normally tightly regulated by a short-loop negative-feedback mechanism, whereby prolactin stimulates activity of tuberoinfundibular dopamine (TIDA) neurones to increase dopamine secretion into the pituitary portal blood. Dopamine inhibits prolactin secretion, thus reducing prolactin concentrations in the circulation back to the normal low level. Activation of this feedback secretion by placental lactogen during pregnancy maintains relatively low levels of prolactin secretion during early and mid-pregnancy. Despite the continued presence of placental lactogen, however, dopamine secretion from TIDA neurones is reduced during late pregnancy. Moreover, the neurones become completely unresponsive to endogenous or exogenous prolactin at this time, allowing a large nocturnal surge of prolactin to occur from the maternal pituitary gland during the night before parturition. In this review, we describe the changing patterns of prolactin secretion during pregnancy in the rat, and discuss the neuroendocrine mechanisms controlling these changes. The loss of response to prolactin is an important maternal adaptation to pregnancy, allowing the prolonged period of hyperprolactinaemia required for mammary gland development and function and for maternal behaviour immediately after parturition, and possibly also contributing to a range of other adaptive responses in the mother. |
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Authors:
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David R Grattan; Frederik J Steyn; Ilona C Kokay; Greg M Anderson; Stephen J Bunn |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-02-08 |
Journal Detail:
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Title: Journal of neuroendocrinology Volume: 20 ISSN: 1365-2826 ISO Abbreviation: J. Neuroendocrinol. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-26 Completed Date: 2008-06-18 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8913461 Medline TA: J Neuroendocrinol Country: England |
Other Details:
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Languages: eng Pagination: 497-507 Citation Subset: IM |
Affiliation:
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Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand. dave.grattan@anatomy.otago.ac.nz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological*
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physiology Analgesics, Opioid / metabolism Animals Dopamine / metabolism Feedback, Physiological / physiology Female Gonadal Steroid Hormones / physiology Humans Lactation / metabolism, physiology Models, Biological Neurons / metabolism, physiology Neurosecretory Systems / physiology* Pregnancy / metabolism, physiology* Prolactin / secretion* Receptors, Prolactin / physiology |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Gonadal Steroid Hormones; 0/Receptors, Prolactin; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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