Document Detail


Pregnancy-induced adaptation in the neuroendocrine control of prolactin secretion.
MedLine Citation:
PMID:  18266946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During pregnancy, neuroendocrine control of prolactin secretion is markedly altered to allow a state of hyperprolactinaemia to develop. Prolactin secretion is normally tightly regulated by a short-loop negative-feedback mechanism, whereby prolactin stimulates activity of tuberoinfundibular dopamine (TIDA) neurones to increase dopamine secretion into the pituitary portal blood. Dopamine inhibits prolactin secretion, thus reducing prolactin concentrations in the circulation back to the normal low level. Activation of this feedback secretion by placental lactogen during pregnancy maintains relatively low levels of prolactin secretion during early and mid-pregnancy. Despite the continued presence of placental lactogen, however, dopamine secretion from TIDA neurones is reduced during late pregnancy. Moreover, the neurones become completely unresponsive to endogenous or exogenous prolactin at this time, allowing a large nocturnal surge of prolactin to occur from the maternal pituitary gland during the night before parturition. In this review, we describe the changing patterns of prolactin secretion during pregnancy in the rat, and discuss the neuroendocrine mechanisms controlling these changes. The loss of response to prolactin is an important maternal adaptation to pregnancy, allowing the prolonged period of hyperprolactinaemia required for mammary gland development and function and for maternal behaviour immediately after parturition, and possibly also contributing to a range of other adaptive responses in the mother.
Authors:
David R Grattan; Frederik J Steyn; Ilona C Kokay; Greg M Anderson; Stephen J Bunn
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-02-08
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  20     ISSN:  1365-2826     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-26     Completed Date:  2008-06-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  497-507     Citation Subset:  IM    
Affiliation:
Centre for Neuroendocrinology and Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand. dave.grattan@anatomy.otago.ac.nz
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological* / physiology
Analgesics, Opioid / metabolism
Animals
Dopamine / metabolism
Feedback, Physiological / physiology
Female
Gonadal Steroid Hormones / physiology
Humans
Lactation / metabolism,  physiology
Models, Biological
Neurons / metabolism,  physiology
Neurosecretory Systems / physiology*
Pregnancy / metabolism,  physiology*
Prolactin / secretion*
Receptors, Prolactin / physiology
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 0/Gonadal Steroid Hormones; 0/Receptors, Prolactin; 9002-62-4/Prolactin

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