Document Detail

Pregnancy increases the risk of mortality in West Nile virus-infected mice.
MedLine Citation:
PMID:  17251565     Owner:  NLM     Status:  MEDLINE    
West Nile fever outbreaks in the USA have caused over 700 human deaths, primarily due to neurological disease. The usual transmission route of West Nile virus (WNV) involves mosquito bites; however, alternative routes, including intrauterine infection, have also been reported. Here, the pathogenicity of WNV in mice during gestation has been investigated. An extremely high mortality rate was observed in pregnant mice (98 %, 60/61) compared with non-pregnant mice (52 %, 28/53; P<0.001), independent of the infecting dose or the week of pregnancy. Antibody titres were similar between pregnant and non-pregnant mice and between surviving and non-surviving animals. WNV RNA titres in brains were also similar between pregnant and non-pregnant mice. WNV RNA could be detected in placentas and fetuses. These observations suggest strongly that, in the mouse model, pregnancy increases the risk of severe WNV infection and may help to understand the pathogenic mechanisms involved in WNV infection during pregnancy.
Laura Córdoba; Estela Escribano-Romero; Antonio Garmendia; Juan-Carlos Saiz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of general virology     Volume:  88     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-25     Completed Date:  2007-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  England    
Other Details:
Languages:  eng     Pagination:  476-80     Citation Subset:  IM    
Departamento de Biotecnología, Instituto Nacional de Investigaciones Agrarias, Ctra Coruña km 7.5, 28040 Madrid, Spain.
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MeSH Terms
Antibodies, Viral / blood
Brain / virology
Mice, Inbred BALB C
Pregnancy Complications, Infectious / mortality*,  virology
RNA, Viral / analysis
West Nile Fever / mortality*,  virology
West Nile virus / immunology,  pathogenicity*
Reg. No./Substance:
0/Antibodies, Viral; 0/RNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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