| Pregnancy in women with idiopathic thrombocytopaenic purpura. | |
| | |
MedLine Citation:
|
PMID: 12061285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: Idiopathic thrombocytopaenic purpura (ITP) is a common haematological disorder in young women. The management of ITP in pregnancy is controversial, particularly with regards to the mode of delivery. To date, there is no systematic study of the outcome of these pregnancies in Singapore. AIM: To study the outcomes of pregnancies in Asian women with a proven diagnosis of ITP. MATERIALS AND METHODS: Retrospective study of 27 pregnancies in 18 women managed at the Singapore General Hospital from 1 January 1994 to 30 June 2001. RESULTS: The mean age of the women was 30 years (range, 20 to 41 years) and the mean parity was 1 (range, 0 to 3). Thrombocytopaenia (platelet count < 150 x 10(9)/L) occurred in 18 pregnancies (67%). There were 3 first trimester missed abortions (11%), 1 termination of pregnancy (4%), 1 stillbirth (4%) and 22 livebirths (81%) in this series. The mode of delivery was spontaneous vaginal in 14 women (64%), vacuum extraction in 2 women (9%), elective caesarean section in 5 women (23%) and emergency caesarean section in 1 woman (4%). All liveborn neonates were delivered in good condition at term. Neonatal thrombocytopaenia occurred in 4 neonates (18%). Two neonates had cord platelet counts of less than 50 x 10(9)/L and 1 required therapy with corticosteroids and intravenous immune globulins. No bleeding complications occurred in any of the neonates. CONCLUSION: Our experience supports the increasingly prevalent practice of managing pregnancies in women with ITP with a conservative approach to investigations and treatment. Caesarean sections should be performed for obstetric indications only, given the rarity of bleeding complications in the offspring of these women and the lack of evidence to support its role in the prevention of neonatal intracranial haemorrhage. |
| | |
Authors:
|
K Devendra; L P Koh |
Related Documents
:
|
17479685 - A case of endodermal sinus tumor associated with the first pregnancy and successful man... 1511765 - Routine previous cesarean scar exploration following successful vaginal delivery. is it... 18377545 - Pregnancy in marfan syndrome after aortic root replacement: a case report and review of... 994125 - Chorioamnionitis. 77515 - Alpha-fetoprotein content of amniotic fluid in normal and abnormal pregnancies. 9625365 - Thyroid size and thyroid function during pregnancy: an analysis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Annals of the Academy of Medicine, Singapore Volume: 31 ISSN: 0304-4602 ISO Abbreviation: Ann. Acad. Med. Singap. Publication Date: 2002 May |
Date Detail:
|
Created Date: 2002-06-13 Completed Date: 2002-11-15 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7503289 Medline TA: Ann Acad Med Singapore Country: Singapore |
Other Details:
|
Languages: eng Pagination: 276-80 Citation Subset: IM |
Affiliation:
|
Division of Fetal-Maternal Medicine, Department of Obstetrics and Gynaecology, Singapore General Hospital, Outram Road, Singapore 169608. dharkan@singnet.com.sg |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortion, Spontaneous
/
etiology Adult Anti-Inflammatory Agents / pharmacology, therapeutic use* Asian Continental Ancestry Group Cerebral Hemorrhage / congenital Cesarean Section / statistics & numerical data Delivery, Obstetric / methods*, standards, statistics & numerical data Drug Therapy, Combination Female Fetal Blood / cytology Fetal Death / etiology Humans Immunoglobulins, Intravenous / pharmacology, therapeutic use* Maternal Age Parity Platelet Count Pregnancy Pregnancy Complications, Hematologic / diagnosis, therapy* Pregnancy Outcome Purpura, Thrombocytopenic, Idiopathic / complications, congenital, diagnosis, therapy* Retrospective Studies Singapore Splenectomy Steroids Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents; 0/Immunoglobulins, Intravenous; 0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Are maternal deaths on the ascent in Singapore? A review of maternal mortality as reflected by coron...
Next Document: Gestational diabetes mellitus: a call for systematic tracing.