Document Detail

Pregnancy in women with diabetes mellitus. The beginning.
MedLine Citation:
PMID:  8222464     Owner:  NLM     Status:  MEDLINE    
Before the discovery of insulin in 1921, pregnancies in women with diabetes mellitus were uncommon. Most patients succumbed to ketoacidosis within 1 to 2 years after diagnosis. Insulin therapy restored the fertility of these women, and maternal deaths were nearly eliminated; however, the perinatal mortality rate remained high. Elective preterm deliveries were planned to reduce the stillbirth rate, often resulting in neonatal deaths from respiratory distress syndrome. Furthermore, women with more severe disease were able to become pregnant with a risk of complications due to preeclampsia.
S G Gabbe
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinics in perinatology     Volume:  20     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-02     Completed Date:  1993-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  507-15     Citation Subset:  IM; Q    
Department of Obstetrics and Gynecology, Ohio State University College of Medicine, Columbus.
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MeSH Terms
Diabetes Mellitus, Type 1 / history*
History, 19th Century
History, 20th Century
Pregnancy Outcome
Pregnancy in Diabetics / history*

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