| Pregnancy in the woman with epilepsy: maternal and fetal outcomes. | |
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MedLine Citation:
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PMID: 12528055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnancy in women with epilepsy is associated with increased obstetric risks and increased adverse neonatal outcomes. Prior to conception, folic acid should be administered and the antiepileptic drug (AED) regimen should be optimized. Effective control of maternal seizures with the least risk to the fetus is the goal, preferably using AED monotherapy. Periodic monitoring of total and free AED levels is recommended. The "fetal anticonvulsant syndrome" has been described with all of the AEDs and includes major malformations, minor anomalies, microcephaly, cognitive impairment, intrauterine growth retardation, and infant mortality. The most common major malformations are cleft lip/palate, heart defects, and neural tube defects. Prenatal screening should be offered. Supplemental vitamin K(1) should be given to the mother and newborn to prevent neonatal hemorrhagic disorder. Careful planning and management of any pregnancy in women with epilepsy are essential to increase the likelihood of a healthy outcome for the mother and infant. |
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Authors:
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Page B Pennell |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in neurology Volume: 22 ISSN: 0271-8235 ISO Abbreviation: Semin Neurol Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2003-01-15 Completed Date: 2003-03-21 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8111343 Medline TA: Semin Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 299-308 Citation Subset: IM |
Affiliation:
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Emory Epilepsy Monitoring Unit, Emory University School of Medicine, Atlanta, Georgia 30322, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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adverse effects* Delivery, Obstetric Epilepsy / drug therapy* Female Fetal Diseases / chemically induced*, etiology Fetus / abnormalities Humans Labor, Obstetric Pregnancy / drug effects* Pregnancy Complications* / chemically induced, drug therapy Pregnancy Outcome Prenatal Diagnosis Risk Factors Seizures / drug therapy Women's Health |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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