Document Detail


Pregnancy in the woman with epilepsy: maternal and fetal outcomes.
MedLine Citation:
PMID:  12528055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancy in women with epilepsy is associated with increased obstetric risks and increased adverse neonatal outcomes. Prior to conception, folic acid should be administered and the antiepileptic drug (AED) regimen should be optimized. Effective control of maternal seizures with the least risk to the fetus is the goal, preferably using AED monotherapy. Periodic monitoring of total and free AED levels is recommended. The "fetal anticonvulsant syndrome" has been described with all of the AEDs and includes major malformations, minor anomalies, microcephaly, cognitive impairment, intrauterine growth retardation, and infant mortality. The most common major malformations are cleft lip/palate, heart defects, and neural tube defects. Prenatal screening should be offered. Supplemental vitamin K(1) should be given to the mother and newborn to prevent neonatal hemorrhagic disorder. Careful planning and management of any pregnancy in women with epilepsy are essential to increase the likelihood of a healthy outcome for the mother and infant.
Authors:
Page B Pennell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in neurology     Volume:  22     ISSN:  0271-8235     ISO Abbreviation:  Semin Neurol     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2003-01-15     Completed Date:  2003-03-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8111343     Medline TA:  Semin Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  299-308     Citation Subset:  IM    
Affiliation:
Emory Epilepsy Monitoring Unit, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
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MeSH Terms
Descriptor/Qualifier:
Anticonvulsants / adverse effects*
Delivery, Obstetric
Epilepsy / drug therapy*
Female
Fetal Diseases / chemically induced*,  etiology
Fetus / abnormalities
Humans
Labor, Obstetric
Pregnancy / drug effects*
Pregnancy Complications* / chemically induced,  drug therapy
Pregnancy Outcome
Prenatal Diagnosis
Risk Factors
Seizures / drug therapy
Women's Health
Chemical
Reg. No./Substance:
0/Anticonvulsants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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