Document Detail

Pregnancy in a woman with chronic neutrophilic leukemia.
MedLine Citation:
PMID:  23344408     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic neutrophilic leukemia is a rare myeloproliferative disorder in women of reproductive age.
CASE: A pregnant woman with an established diagnosis of chronic neutrophilic leukemia presented at 26 weeks of gestation with splenomegaly, thrombocytopenia, leukocytosis, and anemia. Thrombocytopenia was refractory to medical treatment and, in part, was attributed to splenic sequestration. She delivered a healthy neonate at 35 weeks of gestation by repeat cesarean delivery under general anesthesia. Her preoperative platelet count was 30,000/mL and she was transfused platelets throughout the perioperative period. Her postpartum course was complicated by intraabdominal hemorrhage and severe preeclampsia. She recovered with intensive medical and surgical management.
CONCLUSION: Chronic neutrophilic leukemia poses difficult challenges during pregnancy and requires a multidisciplinary approach.
Jolyn Taylor; Gail J Roboz; Rebecca N Baergen; Mehmet R Genc
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  121     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-24     Completed Date:  2013-04-02     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  457-60     Citation Subset:  AIM; IM    
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MeSH Terms
Abdominal Cavity / surgery
Anemia / etiology
Antineoplastic Agents / therapeutic use
Cesarean Section, Repeat
Erythrocyte Transfusion
Infant, Newborn
Leukemia, Neutrophilic, Chronic / complications,  therapy*
Leukocytosis / etiology
Platelet Transfusion
Postoperative Hemorrhage / etiology,  surgery
Pre-Eclampsia / drug therapy
Pregnancy Complications, Neoplastic / therapy*
Splenomegaly / etiology
Thrombocytopenia / etiology
Grant Support
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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