| Pregnancy in sickle cell disease: maternal and fetal outcomes in a population receiving prophylactic partial exchange transfusions. | |
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MedLine Citation:
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PMID: 20846778 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To describe pregnancy outcomes for pregnant women with sickle cell disease (SCD) receiving prophylactic transfusions. STUDY DESIGN: This retrospective case-control study compared pregnancy outcomes among women with SCD receiving prophylactic transfusions and women without any hemoglobinopathy, matched for ethnicity, parity, age and hospital. RESULTS: The study included two groups of pregnancies: 128 in women with SCD (95 with SS phenotype and 33 with SC) and 128 in women with AA phenotype. No woman died. Two perinatal deaths (2.1%) and five alloimmunizations (5.3%) occurred, all in the SS group. Compared with the control group, HbSS disease was more often associated with pre-eclampsia (9.4% versus 2.3%, p=.03), preterm delivery (15.8% versus 6.2%, p=.01), birth weight <10th percentile (13.7% versus 3.9%, p=.008) and caesarean delivery (73.6% versus 26.4%, p<.01). CONCLUSION: Despite prophylactic blood transfusions, SCD remains a severe complicating factor in pregnancy. The policy of systematic transfusions should be analyzed in a sufficiently large randomized trial. |
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Authors:
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C Ngô; G Kayem; A Habibi; A Benachi; F Goffinet; F Galactéros; B Haddad |
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Publication Detail:
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Type: Journal Article Date: 2010-09-16 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 152 ISSN: 1872-7654 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 138-42 Citation Subset: IM |
Copyright Information:
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Copyright © 2010. Published by Elsevier Ireland Ltd. |
Affiliation:
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Université Paris XII-Créteil, Obstetrics and Gynecology, CHI Créteil, France. charlotte.ngo@curie.net |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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